The International Transporter Consortium (ITC) has recently described seven transporters of particular relevance to drug development. Based on the second ITC transporter workshop in 2012, we have identified additional transporters of emerging importance in pharmacokinetics, interference of drugs with transport of endogenous compounds, and drug-drug interactions (DDIs) in humans. The multidrug a...

Background: Hyperbilirubinemia and feeding problems are the most common indications for readmission in the first 2 weeks of life. Inadequate oral intake causes weight loss and increases the bilirubin enterohepatic circulation Objective: To describe the association between total serum bilirubin (TSB) levels and weight loss in healthy term infants readmitted for hyperbilirubinemia after birth. Me...

Jaundice in the newborn period can be physiologic and is often due to benign causes. Jaundice due to conjugated hyperbilirubinemia extending beyond the second week of life may be an early sign of several cholestatic or metabolic liver diseases, and it requires logical and timely analysis so that specific treatments can be initiated. Alpha-1 antitrypsin deficiency is the most common genetic caus...

CONTEXT Agenesis of the dorsal pancreas is one of the rare congenital malformations of pancreas. The association of agenesis of the dorsal pancreas with pancreatic tumors is extremely rare and only around 9 cases being reported till date. CASE REPORT We report a case of a fifty one year old woman with an agenesis of the dorsal pancreas with periampullary pancreaticobiliary adenocarcinoma. She...

Background: Neonatal hyperbilirubinemia occurs in about 60% of newborns. If not managed properly, it can progress to severe neonatal hyperbilirubinemia (SNNJ) leading to death or permanent disability. Aim: To assess nurse's knowledge and practice about neonate with hyperbilirubinemia. Subjects: 41 nurses working in nine districts hospital in Minia governorate each district one hospital and from...

AIM AND SCOPE We conducted this study to estimate the incidence of hyperbilirubinemia in a small neonatal care unit in Catania, Italy, and to determine the underlying causes, which would be of value in identifying and implementing strategies to prevent morbidity from this condition. BACKGROUND Management of hyperbilirubinemia remains a challenge for neonatal medicine because of the risk for s...

A69-year-oldmanpresentedwith right hypochondriac pain accompanied by postprandial nausea and vomiting for 2 months. Additional symptoms included fever and fatigue for 4 days. There was associated history of weight loss of approximately 6 kg over the past few months. Vital signs were normal, and he was febrile (38.3°C). His skin and sclerae weremildly icteric. He had no signs of liver failure. H...

We report on a female neonate with severe onset of congenital cytomegalovirus (CMV) infection. She was noted to have cerebral ventriculomegaly on antenatal ultrasound, and presented with petechia after birth. Laboratory tests revealed severe thrombocytopenia (platelet count, 11,000/mm3) and hypoglycemia (serum glucose level, 5 mg/dl). Hepatosplenomegaly with elevated hepatic enzymes, retinitis,...

Jaundice (also known as hyperbilirubinemia) is a yellowish-greenish pigmentation of the sclera and skin caused by an increase in bilirubin production or a defect in bilirubin elimination. Management of hyperbilirubinemia is one of the most common reasons for readmission of a newborn. Prolonged unconjugated hyperbilirubinemia can result in acute bilirubin encephalopathy and eventually develop in...