In a diploid, outbreeding organism like man the deleterious mutants carried by the population are only partly expressed in each generation, being largely concealed by heterozygosis with more favorable alleles. However, the total hidden-mutational damage carried by the population can be estimated indirectly from the detrimental effects of consanguineous marriage. This method, applied to mortalit...

Dental agenesis is a commonly encountered dental anomaly that affects more than 20% of the human population. It can be categorized as hypodontia, oligodontia, or anodontia. Oligodontia occur either an isolated finding part syndrome, and causative factor environmental genetic. : This report describes three cases isolated, non-syndromic tooth with single/ multiple missing permanent teeth. No othe...

The effects of consanguineous marriages on couples' fertility and sterility were explored through an interview survey of 20 626 women, chosen randomly from the rural and urban areas of the North Arcot District of Tamil Nadu State. Qualified women investigators obtained relevant information about reproductive performances of all married women resident in well defined rural and urban samples chos...

Using data on 9762 women from the 1997 Yemen Demographic and Maternal and Child Health Survey, this paper examines the prevalence and socioeconomic correlates of consanguineous marriages in Yemen. The results indicate that 40% of marriages are consanguineous, over 85% of which are between first cousins. The prevalence of consanguineous marriages appears to have increased over time, particularly...

There is little information on inbreeding during the critical early years of human existence. However, given the small founding group sizes and restricted mate choices it seems inevitable that intrafamilial reproduction occurred and the resultant levels of inbreeding would have been substantial. Currently, couples related as second cousins or closer (F ≥ 0.0156) and their progeny account for an...

Biallelic germline mutations in the mismatch repair genes, including MLH1, MSH2, MSH6 or PMS2, lead to a recessive constitutional mismatch repair-deficiency (CMMR-D) syndrome characterized by early onset malignancies in children and young adults. Because consanguinity unmasks autosomal recessive disorders, we hypothesized that the frequency of CMMR-D is inflated in the highly consanguineous pop...

Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder caused by alteration in CYP21 gene which ultimately leads to 21-hydroxylase deficiency. The present study aimed at evaluation of 2 common mutations viz, Intron 2 Splice (INT2S) mutation and 8 bp deletions in exon 3 of CYP21 gene and to establish their frequencies in Kashmir population (North India). The mutations were teste...

BACKGROUND The aim of this retrospective study was to describe the distribution of the non-syndromal supernumerary teeth (NSST) in a population of patients who attended the clinics of Riyadh Colleges of Dentistry and Pharmacy (RCsDP), Riyadh, Saudi Arabia. MATERIALS AND METHODS The study reviewed 1521 panoramic radiographs of Saudi and non-Saudi subjects who attended RCsDP clinic from Novembe...

OBJECTIVE With 20-30% of all marriages occurring between first cousins, increasing attention in Jordan is now given to role of consanguinity in the occurrence of genetic diseases. The objective of this study is to define the specific categories of genetic disorders associated with consanguineous marriages. METHODS Etiological categories and consanguinity rates were studied among 623 families ...

Consanguineous marriages are more common in south India primarily because of social and cultural factors. Possibility a child consanguineous married couple, suffering from genetic diseases, congenital deformities auto recessive disorder is than offspring non-consanguineous couple. prevalent rural area lack awareness about consequences. Hence the aim study was to educate adolescents regarding ma...