The impact of consolidation on response rates and PFS has recently been demonstrated after induction and autotransplantation upfront in Multiple Myeloma (MM). We further showed that patients in ≥VGPR following the intensification procedure benefited most from consolidation. Question remains as to the benefit of consolidation for patients in PR at completion of induction - feature of partial res...

Although the empirical pattern of industry shakeout has been documented for many manufacturing industries, we know little about the processes by which market structure evolves in non-manufacturing service industries. This paper establishes detailed empirical observations about the consolidation of a single non-manufacturing industry, the wholesale distribution of pharmaceuticals. These observat...

Memory consolidation involves the process by which newly acquired information becomes stored in a long-lasting fashion. Evidence acquired over the past several decades, especially from studies using post-training drug administration, indicates that emotional arousal during the consolidation period influences and enhances the strength of the memory and that multiple different chemical signaling ...

Cloud Computing is a new paradigm of distributed computing that offers virtualized resources and services over the Internet. To offer Infrastructure-as-a-Service (IaaS) many Cloud providers uses a large data center which usage ranges 5% to 10% of capacity in average. In order to improve Cloud data center management and resources usage a Virtual Machine (VM) consolidation technique can be applie...

The early 1990s have been a time of fiscal stress for local governments in the United States with school districts particularly hard hit. This article presents the results of a detailed study of potential cost savings from consolidation of New York school districts. It extends past research on consolidation by developing a theoretical framework which distinguishes several dimensions of economie...

In memory consolidation, declarative memories which initially require the hippocampus for their recall, ultimately become independent of it. Consolidation has been the focus of numerous experimental and qualitative modeling studies, but only little quantitative exploration. We present a consolidation model in which hierarchical connections in the cortex, that initially instantiate purely semant...

I. G. Doran and J. D. McKinley, Queen’s University Belfast The paper proposes the use of an approximation, suggested by Hansen, to the exact analytical solution of the Terzaghi consolidation equation, as the basis for the determination of the coefficient of consolidation from the results of a consolidation test using a least squares error adjustment procedure. This is an area of considerable pr...

Server consolidation of virtual machines is very much essential in a cloud environment for energy conservation and cost cutting . Consolidation can be achieved through live migration of virtual machines. We propose a modified bin packing algorithm for Server Consolidation that avoids unnecessary migrations and minimizes the instantiation of new physical servers. We implement ideas from the Firs...

Consolidation and integration have been subjects of interest in recent Chi Solutions, Inc. (Chi) webinars and research projects, as well as ongoing topics of discussion at national industry meetings and seminars. While some use the terms “consolidation” and “integration” interchangeably, they do have different meanings and strategies. Consolidation is about bringing as much testing as possible ...

system at an increasing rate. Merging companies often tout benefits including cost savings and increased care coordination, but serious concerns about market power also need to be raised. It is critically important to scrutinize future mergers because of their impact on an already excessively concentrated healthcare marketplace. This research brief looks at the types of consolidation, the facto...