This paper presents a new rolling circle amplification (RCA) technique using stem-loop primers (SLP). The technique enables detection of target DNA by either linear or exponential amplification (SLP-lRCA and SLP-eRCA) in both liquid and solid phases. For solid-phase detection, SLP-eRCA detects nucleic acids in four steps: (1) covalently immobilize an array of capture probes (CP) on a solid supp...

     Ibuprofen solid dispersions were prepared by the solvent and fusion-solvent methods using polyethylene glycol (PEG), polyvinylpyrrolidone (PVP), eudragit RS PO, eudragit RL PO and hydroxypropylmethylcellulose (HPMC) as carriers to improve physicochemical characteristics of ibuprofen. The prepared solid dispersions were evaluated for the flowability, solubility characteristics and dissoluti...

For the purpose of this Monograph, unless otherwise specified, the term ‘aristolochic acids’ refers to an extract of Aristolochia species comprising a mixture of aristolochic acid I and its demethoxylated derivative, aristolochic acid II. Aristolochia species also contain the related aristolactams, which are phenanthrene cyclic amides (EMEA, 2000). In some of the older literature, it is unclear...

background and objectives: the mobility, bioavailability and environmental fate of heavy metal ions in soil are controlled by sorption onto soil minerals and solid organic matter. the sorption is strongly affected by the presence of various low-molecular-weight organic acids. the main objective of this study was to investigate the effects of oxalic acid on sorption of cd on clay fraction of a s...

We performed an enzymatic screening of synthetic peptides based on β-amyloid precursor protein substrates. The template peptide sequence was a decapeptide derived from our previous study, which determined several effective unnatural amino acids. In this new libraries containing some acid compounds were prepared in the solid phase and digested with β-site amyloid protein-cleaving enzyme. reactio...

quebracho tannin wood adhesive in non formaldehyde approach has low autocondensation rate and needs more press time than formaldehyde-based wood adhesives to produce wood composites. in this study, boric acid was used to increase autocondensation rate of quebracho tannin adhesive to make poplar plywood. the main ingredients of the adhesives include quebracho tannin, naoh, hexamine, boric acid a...

The use of the tetrahydropyranyl (Thp) group for the protection of serine and threonine side-chain hydroxyl groups in solid-phase peptide synthesis has not been widely investigated. Ser/Thr side-chain hydroxyl protection with this acid-labile and non-aromatic moiety is presented here. Although Thp reacts with free carboxylic acids, it can be concluded that to introduce Thp ethers at the hydroxy...

sulfonic acid-based precursors (sap) play an important role in tailoring mesoporous silica’s and convert them to a solid acid catalyst with a bronsted-type nature. these kinds of solid acids contribute to sustainable and green chemistry by their heterogeneous, recyclable, and high efficiency features. therefore, knowing the properties and reactivity of saps can guide us to manufacture a sulfona...