BACKGROUND Women with an initial breast cancer diagnosis are at elevated risk of developing subsequent cancer in the contralateral breast. Studies of reproductive factors and contralateral breast cancer (CBC) have provided inconsistent results. METHODS We employed a case-control study nested within five population-based cancer registries in the United States and Denmark to examine association...

91 Ahmad Kaviani, MD Amin Safavi, MD Department of Surgery Tehran University of Medical Sciences Tehran, Iran; and Department of Research Kaviani Breast Diseases Institute Tehran, Iran Rasool Mirsharifi, MD Department of Surgery Tehran University of Medical Sciences Tehran, Iran Sir: O breast surgery (OBS) has opened a new chapter in breast conservation for breast cancer treatment and, as impli...

Introduction: The incidence of breast cancer increases with the rate of 1-2% at the world. Radiation therapy is one of the available choices for breast cancer treatment. The single isocentre half-beam block technique is considered as a standard technique to avoid hot and cold spots within the PTV. The major advantage of half beam technique is that the both contralateral breast...

INTRODUCTION Contralateral mediastinal shift due to pleural mesothelioma tissue, rather than a pleural effusion, is an unusual clinical feature of mesothelioma. CASE PRESENTATION A 63-year-old woman with a past history of treated invasive ductal carcinoma of the breast presented with breathlessness and chest pain. Her chest radiograph revealed contralateral mediastinal shift and drainage of o...

BACKGROUND Nipple creation using the C-V flap technique is often the final step in breast reconstruction. The aim of this study was to subjectively and objectively assess the cosmetic outcomes and satisfaction of patients undergoing C-V flap nipple reconstruction. METHODS Subjective assessments of patient satisfaction with the neo-nipple were recorded by visual analogue scoring (VAS; 0...

BACKGROUND Prone whole breast irradiation (WBI) leads to reduced heart and lung doses in breast cancer patients receiving adjuvant radiotherapy. In this feasibility trial, we investigated the prone position for whole breast + lymph node irradiation (WB + LNI). METHODS A new support device was developed for optimal target coverage, on which patients are positioned in a position resembling a ph...

Background: Breast reconstruction by using the rectus abdominis muscle (transverse rectus abdominis myocutaneous, TRAM) flaps is a common procedure that has been per­ formed since the 1990s. Ipsilateral TRAM flaps were proven to be as safe as contralateral flaps for breast reconstruction. However, studies comparing the aesthetic outcomes of the two procedures are poorly described in the literat...

Uterine carcinosarcoma (malignant mixed Müllerian tumor, MMMT) is a rare aggressive malignant tumor, which demonstrates both malignant epithelial (carcinoma) and mesenchymal (sarcoma) components. Synchronous uterine carcinosarcoma and contralateral breast cancer in patient received tamoxifen treatment had not been reported. We present a case of uterine carcinosarcoma co-occurrenced with contral...

Women who carry a mutation of BRCA1 or BRCA 2 gene have an increased lifetime risk of breast cancer as high as 50-85% (Matloff et al., 2000; Antoniou et al., 2003; King et al., 2003). The annual risk for contralateral cancer for mutated BRCA1 or BRCA2 carrier is increased by approximately 3% and the overall risk may be as high as 52% by age 70 years. Options for carriers include early and regul...

Central pathology review of ductal carcinoma in situ from 1,456 patients enrolled in National Surgical Adjuvant Breast and Bowel Project (NSABP) protocol B-24 was performed to determine predictors for ipsilateral breast tumor recurrences and contralateral breast cancers. Findings after a median follow-up time of 10.5 years revealed ductal comedo necrosis, micropapillary histologic tumor type, a...