HLA-matched UC blood-derived multipotent stem cells were directly transplanted into the injured spinal cord site of a 37-year-old female patient suffering from spinal cord injury (SPI). In this case, human cord blood (UCB)-derived multipotent stem cells improved sensory perception and movement in the SPI patient's hips and thighs within 41 days of cell transplantation. CT and MRI results also s...

In this work we describe a 3-year-old boy with hepatitis-associated aplastic anemia (HAAA) treated successfully with autologous cord blood transplantation combined with immunosuppressive therapy. There is little previous experience in the utility of autologous cord blood transplantation in the treatment of HAAA. Nowadays, for patients born after 1980, an HLA matched sibling donor is not usually...

1. Gluckman E, Rocha V, Boyer-Chammard A, et al. Outcome of cord-blood transplantation from related and unrelated donors. N Engl J Med 1997;337: 373–81. 2. Rubinstein P, Carrier C, Scaradavou A, et al. Outcomes among 562 recipients of placental-blood transplants from unrelated donors. N Engl J Med 1998;339: 1565–77. 3. Rocha V, Wagner JE Jr, Sobocinski KA, et al. Graft-versus-host disease in ch...

A 65-year-old Japanese male with therapy-related myelodysplastic syndrome was admitted for unrelated cord blood transplantation. A cord blood unit from a male donor was obtained from the Japan Cord Blood Bank Network. The patient then received a conditioning regimen consisting of fludarabine, intravenous busulfan, and total body irradiation. Successful engraftment was obtained. The bone marrow ...

Umbilical cord blood (UCB) transplantation is being used as an alternative source of haematopoietic stem cells for bone marrow reconstitution. Umbilical cord blood (UCB) transplantation is being used as an alternative source of haematopoietic stem cells for bone marrow reconstitution. Separation and processing of UCB samples in large numbers for storage in cord blood banks ideally needs to be p...

Transplantation of umbilical cord blood cells is currently widely used in modern cell therapy. However, the limited number of hematopoietic stem and progenitor cells (HSPCs) and prolonged time of recovery after the transplantation are significant limitations in the use of cord blood. Ex vivo expansion with various cytokine combinations is one of the most common approaches for increasing the num...

BACKGROUND Hurler's syndrome (the most severe form of mucopolysaccharidosis type I) causes progressive deterioration of the central nervous system and death in childhood. Allogeneic bone marrow transplantation before the age of two years halts disease progression and prolongs life, but many children lack a bone marrow donor. We investigated the feasibility of using cord-blood transplants from u...

background: unrestricted somatic stem cells (ussc) are cord blood stem cells that have been considered as candidates for the regulation of immune responses. therefore, potential exists for their use in the suppression of immune response after transplantation surgery. objective: the aim of this study was evaluation of the effect of ussc on mixed lymphocyte reaction (mlr) as a model for graft rej...

A 62-year-old female was diagnosed with acute myeloid leukemia (AML) t(16;21)(p11;q22). She achieved complete hematological remission after induction therapy and underwent umbilical cord blood stem cell transplantation (CBT). At 150 days the CBT, a bone marrow examination revealed relapse. We treated patient venetoclax plus azacitidine as salvage therapy. After five cycles of therapy, died due ...

The term “cord blood” is used for blood that is drawn from the umbilical cord and the placenta after a baby is born. Up until recently this afterbirth was discarded as medical waste. Cord blood contains stem cells that may be frozen for later use in medical therapies, such as stem cell transplantation or regenerative medicine. The umbilical cord and placenta are rich sources of stem cells. Thes...