PURPOSE We designed the current study to determine the protective effects of lornoxicam, a cyclooxygenase (COX) inhibitor, on recurrent herpetic stromal keratitis (HSK) and the nuclear factor-kappaB (NF-kappaB)-mediated mechanism in mice. METHODS A corneal latent herpes simplex virus-1 (HSV-1) infected mouse model was established. Six weeks later, Ultraviolet B (UVB) irradiation induced the r...

OBJECTIVE Corneal ulceration secondary to trauma commonly affects marine mammals, often with opportunistic secondary bacterial or fungal infections. This report characterizes the combined use of auriculopalpebral and ophthalmic nerve blocks, adipose-derived stem cells, and subconjunctival injections for successful treatment of corneal trauma and infection in dolphins. ANIMAL STUDIED An 11-yea...

The hereditary corneal dystrophies are remarkable in that only rarely do sufficient opacifications exist at birth or appear during infancy to merit both the prefix "congenital", i.e. a disturbance present at birth, and "dystrophy", i.e. a disturbance developing on a hereditary basis in apparently normal tissue. The term as used has referred to a bilateral symmetrical diffuse opacification of th...

Microbial keratitis is a major cause of corneal opacity and loss of vision worldwide. Ulcerative microbial keratitis remains a leading cause of blindness worldwide. The most common causative organisms are bacteria, although fungi and protists can also cause keratitis. Bacterial keratitis is potentially more devastating ocular infection. The most common bacteria associated with corneal ulcer are...

PURPOSE The transformation of quiescent keratocytes to active phenotypes and the ensuing fibrotic response play important roles in corneal scar formation. This study aims to observe the antifibrotic effect of peroxisome proliferator-activated receptor-gamma (PPARgamma) agonist on corneal fibroblasts cultured in vitro, and to explore the potential application of peroxisome proliferator-activated...

CASTROVEJO (1955) stated that opacities of the cornea, provided that they did not involve the whole thickness might be removed by clean dissection of the affected external layers. If infection, formation of granulation tissue, or revascularization is prevented during the post-operative period, the epithelium grows over the dissected area, the cornea remains transparent or fairly transparent, an...

A 5-week-old male presented with Peters' anomaly. Corneal transplantation was deferred and the patient underwent an optical sector iridectomy in his better eye with central leukoma and iridocorneal adhesions. At six months following surgery, there was a decrease in corneal opacity. The most recent ophthalmic examination was performed at age 42 months. The cornea was considerably clearer, and th...

The hereditary corneal dystrophies are remarkable in that only rarely do sufficient opacifications exist at birth or appear during infancy to merit both the prefix "congenital", i.e. a disturbance present at birth, and "dystrophy", i.e. a disturbance developing on a hereditary basis in apparently normal tissue. The term as used has referred to a bilateral symmetrical diffuse opacification of th...

BACKGROUND A new type of corneal opacity with prominent corneal nerve fibers as an ocular complication of spondyloepiphyseal dysplasia tarda (SEDT). CASE A 58-year-old woman, diagnosed with SEDT at 5 years of age, underwent a complete ophthalmological examination. OBSERVATIONS The patient had no complaints and no history of eye disease. No relatives were reported to have suffered from SEDT....

BACKGROUND An uncommon case of stromal keratitis and anterior uveitis due to herpes simplex virus type 2 (HSV-2) is reported. CASE The patient was a 3-year-old boy admitted for conjunctival injection of the right eye of unknown cause, accompanied by corneal opacity and anterior uveitis. OBSERVATIONS High titers of antibodies against HSV and Epstein-Barr virus (EBV) were found in blood sampl...