BACKGROUND: Matrix metalloproteinases (MMPs) have been implicated in the pathogenesis of arterial aneurysms through increased proteolysis of extracellular matrix proteins. Increased proteolysis due to elevated matrix degrading enzyme activity in the arterial wall may act as a susceptibility factor for the development of coronary aneurysms. The aim of this study was to investigate the associatio...

Abstract Background Giant coronary artery aneurysms (GCAA) are a rare disease entity with an estimated incidence of 0.02%. Atherosclerosis is the most common underlying factor in adulthood. Management guidelines lack support large-scale studies. Case presentation We present case 58-year-old Caucasian male complaints stable dyspnea who was found to have GCAA right (RCA). Further evaluation revea...

Giant coronary artery aneurysms are rare clinical entities. We report the case of a 49-year-old man who presented with dyspnoea and exertional chest pain. Investigations confirmed an aneurysmal right coronary artery measuring 4 cm with a fistulous communication to the right atrium. Following right atriotomy, the fistula was oversewn and the aneurysmal right coronary artery ligated at its origin...

Submitted for the DFD10 Meeting of The American Physical Society Hemodynamic simulations in coronary aneurysms of a patient with Kawasaki Disease DIBYENDU SENGUPTA, ALISON MARSDEN, Mechanical and Aerospace Engineering Dept, UCSD, JANE BURNS, Pediatrics Dept, UCSD — Kawasaki Disease is the leading cause of acquired pediatric heart disease, and can cause large coronary artery aneurysms in untreat...

Coronary aneurysms represent anomalies identified in 0.15%-4.9% of patients undergoing coronary angiography. At present, there is no uniform definition of this pathology. Aneurysms of the left main coronary artery (LMCA) are extremely uncommon, with an incidence of 0.1%. It has been demonstrated that atherosclerosis is the main cause of these anomalies in adults, and Kawasaki disease in childre...

BACKGROUND AND PURPOSE With the increased investigation of cerebral arteries using magnetic resonance angiography in the general population, the detection of unruptured intracranial aneurysms (UIAs) has increased. Understanding the distribution and factors associated with UIAs might be helpful for understanding the pathomechanism. METHODS Subjects who underwent magnetic resonance angiography ...

A56-year-old, previously healthy man presented with a painless pulsatile tumor of the right neck (Figure 1A). The remaining clinical and neurological examination was unremarkable. Duplex sonography, CT angiography, and digital substraction angiography revealed large aneurysms of both common and internal carotid arteries (Figure 1B and 1C). Aneurysms of the brachiocephalic and both subclavian ar...

Aneurysms of the coronary arteries are rare, and it is only after the advent of coronary arteriography that they have been diagnosed in life. They may be due to atherosclerosis, necrotizing arteritis, myocotic emboli, syphilis, or trauma, and occasionally they are congenital. The prognosis appears to be poor and death can occur suddenly from rupture, peripheral coronary embolism, or bacterial e...

OBJECTIVES To determine initial intravenous gammaglobulin (IVIG) treatment failures in Kawasaki disease (KD) and to report the outcome of retreatment and our use of pulse intravenous (IV) methylprednisolone and cyclophosphamide in patients with persistent KD. STUDY DESIGN Retrospective analysis of the treatment and response of children with KD over 3 years. RESULTS Fifty (77%) of 65 patient...

Coronary artery aneurysms developed in a 43 year old man who had suffered an acute myocardial infarction at the age of 30. In childhood he had had an illness that was consistent with Kawasaki disease, and it is suggested that the proximal discrete aneurysms and myocardial infarction may be the adult sequelae of this.