• A two-phase individual-level model was developed to evaluate the costeffectiveness of eltrombopag treatment in thrombocytopenic HCVpatients over a lifetime horizon. • Individual-level models are more flexible and provide more accurate estimations than Markov approaches. • A set of mathematical distributions were developed using data from trials ENABLE 1 and 22 and local studies3,4, to describ...

have been introduced in a numberof countries, butthe evidence base to supportthemislimited.Inparticular there are very feweconomic evaluations, which are crucial if decision-makers are to have a better understanding of how scarce resources canbe used appropriately.This paperdiscusses the different approaches used in economic evaluations and shows how these differ inthewayinwhich outcomes aremea...

Building modern telemetry systems is fraught with challenges involving subsystem integration, the role and management of data, scalability issues, disparate technologies, concerns about costeffectiveness and more. This article addresses today’s challenges with a solution based on adopting a data-oriented architecture and relying on a standards-based, integrated highperformance middleware platfo...

Electrochemical bubbling transfer of graphene is a technique with high industrial potential due to its scalability, timeand costeffectiveness, and ecofriendliness. However, the graphene is often damaged due to the turbulence and the trapped bubbles formed by the direct H 2 O and H permeation through the supporting polymer. We invent a graphene mechanical support of polyethylene terephthalate fo...

Background The goal of public health interventions is to move the distribution of life style risk factors in a healthier direction to decrease disability-causing disease and improve quality of life in the population. We recently presented a novel method to estimate the population-level impact of a public health intervention, using changes in the distribution curve of the outcome of interest. Th...

Agricultural extension continues to offer hope for improving the lives of rural poor in the developing world. Yet the difficulty of achieving that goal persists. This paper proposes a four-stage decision tree for implementing and evaluating the economic sustainability of extension programs that focuses on sources, delivery methods, evaluations, and fiscal support. It then evaluates the costeffe...

Risk assessment of patients with non–ST-elevation acute coronary syndromes (NSTEACS) plays an important role in determining the prognosis. This enhances the costeffectiveness of patient care by allowing evidence-based treatments (such as antiplatelet, anti-thrombotic, and revascularization therapies) to be targeted at the patients who are most likely to benefit from their use. The clinical hist...

In order to meet the energy demands from industrial processes, utility plants must convert fuel and water into steam, electricity, and rotational power. Site utility systems are operated with different scenarios or operating conditions, due to variable conditions, such as different electric power tariffs, changing load in processes and variable ambient temperature. A novel methodology for the d...