A new series of peptide-like derivatives containing different aromatic amino acids andpossessing pharmacophores of COX-2 inhibitors as SO2Me or N3 attached to the para positionof an end phenyl ring was synthesized for evaluation as selective cyclooxygenase-2 (COX-2)inhibitors. The synthetic reactions were based on the solid phase peptide synthesis methodusing Wang resin. One of the analogues, i...

As a continuous research for discovery of new COX-2 inhibitors, chemical synthesis, in vitro biological activity and molecular docking study of anew group of 1,4-dihydropyridine (DHP) derivatives were presented. Novel synthesized compounds possessing a COX-2 SO2Me pharmacophore at the para position of C-4 phenyl ring, different hydrophobic groups (R1) at C-2 position and alkoxycarbonyl groups (...

background: breast cancer is the most common cancer after lung cancer and the second cause of death. in this study we compared weibull and lognormal cure models with cox regression on the survival of breast cancer. study design: a cohort study. methods: the current study retrospective cohort study was conducted on 140 patients referred to ali ibn abitaleb hospital, rafsanjan southeastern iran f...

background and purpose: leukemia is the most prevalent type of cancer in children and its prognostic factors vary in different geographic locations. the aim of this study was to estimate the 5 years survival rate of children suffering from leukemia in kerman, iran and to investigate the factors which might influence it. materials and methods: this was a cohort study conducted on patients with a...

background: the incidence of restenosis in patients suffering from coronary artery disease after undergoing angioplasty is of paramount importance. accordingly, this study aimed to investigate factors affecting the time of the first incidence of restenosis in patients undergone angioplasty in the city of zanjan, iran.   methods: this retrospective cohort study was conducted on 421 patients who ...

background: cyclo-oxygenase-2 (cox-2) is an early response gene that is induced by growth factors, oncogenes and carcinogens and its expression is increased in various tumors. increased expression of cox-2 plays a signifi cant role in the development and growth of tumors by interfering in biological processes such as cell division, cellular immunity, cell adhesion, apoptosis, and angiogenesis. ...

Nonsteroidal anti-inflammatory drugs (NSAIDs) act mainly via inhibition of prostaglandins synthesis by inhibition of cyclooxygenase (COX) isoenzymes (COX1 and COX 2). Selective COX-2 inhibitors which are also known as coxibs provide the main therapeutic effects of NSAIDs. Zarghi et al. reported 6-benzoyl-2-(4-(methylsulfonyl)phenyl)quinoline-4-carboxylic acid (AZGH 101) as a novel derivative of...

conclusions the present study detected more accurate results for ann method compared to those of cox ph model to analyze the survival of patients with liver transplantation. furthermore, the order of effective factors in patients’ survival after transplantation was clinically more acceptable. the large dataset with a few missing data was the advantage of this study, the fact which makes the res...