Regulation of myosin light chain phosphatase (MLCP) via protein kinase C (PKC) and the 17 kDa PKC-potentiated inhibitor of myosin light chain phosphatase (CPI-17) has been reported as a Ca(2+) sensitization signaling pathway in smooth muscle (SM), and thus may be involved in tonic vs. phasic contractions. This study examined the protein expression and spatial-temporal distribution of PKCα and C...

Calpain is a calcium-dependent cysteine protease that is implicated in calcium-dependent cell death, and calpain inhibitors are generally considered as inhibitors of apoptosis. To the contrary, in the present study, we found that calpain inhibitor II (CPI-2) triggers rapid apoptosis in acute lymphoblastic leukemia (ALL) and non-Hodgkin's lymphoma (NHL) cells. All target cell lines were killed b...

Control-flow hijack attacks remain a major security problem, despite many years of research aimed at mitigating them. Code-Pointer Integrity (CPI) [2] is the first protection mechanism that systematically prevents all such attacks while keeping performance overhead low. In the upcoming S&P’15 paper, Evans et al. [1] claim that CPI can be bypassed on x86-64 and ARM architectures. This poster is ...

This paper examines the effects of multithreaded pipelining on the CPI (cycles per instruction) of a RISC processor. The desired CPI in a conventional (single-threaded) RISC processor is one instruction per cycle. However, the CPI is typically more than one because of data hazards, control hazards, and resource hazards in the pipeline. A multi-threaded processor performs a context switch betwee...

This paper provides the first estimates of overall CPI bias prior to the 1970s and new estimates of bias since the 1970s. It finds that annual CPI bias was 0.1 percent between 1888 and 1919 and rose to 0.7 percent between 1919 and 1935. Annual CPI bias was 0.4 percent in the 1960s and then rose to 2.7 percent between 1972 and 1982 before falling to 0.6 percent between 1982 and 1994. The finding...

INTRODUCTION Several neuroimaging studies have suggested that patients with chronic primary insomnia (CPI) exhibit anatomical and functional alterations of the brain, but the temporal regularity in spontaneous neuronal activity remains unknown. Here, brain entropy (BEN), a data-driven method used to measure the signal regularity of a time series, was applied for the first time to investigate ch...

We have previously demonstrated that ERK/PKC signaling pathways play a key role in the regulation of Ca 2+ sensitivity and contractility of the uterine artery. The present study tested the hypothesis that ERK and PKC differentially regulated myosin light chain phosphatase activity by phosphorylation of MYPT1 and CPI-17. Agonist-induced contractions and phosphorylation of MYPT1/Thr 696 , MYPT1/T...

To facilitate life span research on depressive symptomatology, a depressive symptom scale for the California Psychological Inventory (CPI) is needed. The authors constructed such a scale (the CPI-D) and compared its psychometric properties with 2 widely used self-report depression scales: the Beck Depression Inventory and the Center for Epidemiological Studies Depression Scale. Construct validi...

In this work we present Cutting Plane Inference (CPI), a Maximum A Posteriori (MAP) inference method for Statistical Relational Learning. Framed in terms of Markov Logic and inspired by the Cutting Plane Method, it can be seen as a meta algorithm that instantiates small parts of a large and complex Markov Network and then solves these using a conventional MAP method. We evaluate CPI on two task...