Phagocytosis of foreign pathogens by cells of the immune system is a vitally important function of innate immunity. The phagocytic response is initiated when ligands on the surface of invading microorganisms come in contact with receptors on the surface of phagocytic cells such as neutrophils, monocytes/macrophages, and dendritic cells. The complement receptor CR3 (CD11b/CD18, Mac-1) mediates t...

The CR3 activation domain of the human adenovirus E1A protein stimulates transcription by forming protein-protein interactions with DNA sequence-specific binding factors and components of the TFIID complex. Here, we demonstrate that CR3 can complex with the extreme C-terminal 105 amino acids of the human TATA box binding-factor-associated protein, hTAF(II)135. Furthermore, the C-terminal region...

The preparation and structures of seven compounds that contain the Cr3(dpa)4(2+) core (dpa = the anion di(2-pyridyl)amide) are reported. The magnetic properties of several have been measured. In each case there are anionic ligands at each end of the Cr3(6+) chain, sometimes identical (2Cl-, 2CCPh-), sometimes different (Cl-, BF4-; Cl-, PF6-). Several of these compounds have a symmetrical arrang...

Various chromium-containing catalysts were tested for the total oxidation of trichloroethylene (TCE) as a model reaction for the catalytic combustion of chlorinated organic pollutants. A spinel-type cobalt chromite (CoCr2O4) among others was proven to be a very promising catalyst showing higher activity and higher CO2 selectivity than traditional alumina supported chromia. Even if both Cr3+ and...

Five metallic cations (Fe3+, Cr3+, Cal+, Mg2+, Mn2+; concentration range, 1.85 X 10-4 to 37 X 10-4 M) were incorporated individually as chlorides into nutrient broth and agar media used for the recovery of phenol-treated Escherichia coli. The effects observed varied with the concentration and the ionic species. In nutrient agar, Fe3+ and Cr3+ were generally beneficial but were toxic at 37 X 10-...

Citation: Yang X, Pan Y, Xu X, Tong T, Yu S, Zhao Y, Lin L, Liu J, Zhang D and Li C (2018) Sialidase Deficiency in Porphyromonas gingivalis Increases IL-12 Secretion in Stimulated Macrophages Through Regulation of CR3, IncRNA GAS5 and miR-21. Front. Cell. Infect. Microbiol. 8:100. doi: 10.3389/fcimb.2018.00100 Sialidase Deficiency in Porphyromonas gingivalis Increases IL-12 Secretion in Stimula...

Complement receptor 3 (CR3) activation in microglia is involved in neuroinflammation-related brain disorders and pruning of neuronal synapses. Hypoxia, often observed together with neuroinflammation in brain trauma, stroke, and neurodegenerative diseases, is thought to exacerbate inflammatory responses and synergistically enhance brain damage. Here we show that when hypoxia and an inflammatory ...

CR3 (Mac-1; alphaMbeta2 integrin) functions as both a receptor for the opsonic iC3b fragment of C3 triggering phagocytosis or cytotoxicity and an adhesion molecule mediating leukocyte diapedesis. Recent reports have suggested that a CR3 lectin site may be required for both cytotoxic responses and adhesion. Cytotoxic responses require dual recognition of iC3b via the I domain of CD11b and specif...

We have examined receptors mediating phagocytosis of the intracellular bacterial pathogen, Legionella pneumophila. Three mAbs against the type 3 complement receptor (CR3), which recognizes C3bi, inhibit adherence of L. pneumophila to monocytes by 64 +/- 8% to 74 +/- 11%. An mAb against the type 1 complement receptor (CR1), which recognizes C3b, inhibits adherence by 68 +/- 1%. mAbs against othe...

Integrins are heterodimeric cell surface adhesion and signaling receptors that are essential for metazoan existence. Some integrins contain an I-domain that is a major ligand binding site. The ligands preferentially engage the active forms of the integrins and trigger signaling cascades that alter numerous cell functions. Here we found that the adenylate cyclase toxin (CyaA), a key virulence fa...