This paper illustrates the surgical principles employed in the management of a case of incomplete nasomaxillary dysplasia or Tessier Type 11 Cleft. All pre-operative work-up on this case was performed at The Adelaide Children’s Hospital by members of The South Australian Craniofacial Unit and hospital staff. The surgical treatment was planned and executed by Professor 1. C. van der Meulen who w...

OBJECTIVE To determine the dentoalveolar heights (mm) in skeletal class I normodivergent facial pattern and compare the same heights in male and female subjects. STUDY DESIGN Cross-sectional observational study. PLACE AND DURATION OF STUDY Orthodontics Clinic, The Aga Khan University Hospital, Karachi, from July to October 2009. METHODOLOGY Eighty one subjects were selected from the ortho...

The hormone retinoic acid (RA) has been implicated in the organization of the anteroposterior (AP) body axis. In this paper, we describe the effects of RA on the activity of the RA-inducible retinoic acid receptor-beta 2 (RAR beta 2) promoter. When transgenic embryos carrying a RAR beta 2-lacZ reporter gene were exposed to a single dose of RA between gestational days 8.5 to 10.5, lacZ expressio...

Cleft lip and cleft palate are one of the most common craniofacial anomalies. Infants suffer a lot of difficulty in sucking during the initial few days after birth. There is even psychological stress to the parents due to improper feeding and the infants lose weight and are prone to nutritional insufficiency. Due to recent advancement in the medical field, there is a total repair of cleft lip a...

Presented here is a case of a 8 year old boy with typical clinical manifestations of Acrocallosal syndrome. The characteristic features of this syndrome are craniofacial abnormalities, distinctive digital malformation, mental retardation. The clinical and major nosologic aspects of this condition are discussed.

An intergroup comparison of cephalometric landmark configurations by the finite-element method elegantly depicts the algebra of some of the size and shape change measures that one may define by reference to those landmarks. In studies of mean differences between groups, the statistical analysis of these finite elements is equivalent to competent statistical analysis of the same data using any o...

Apert syndrome, characterised by craniosynostosis, craniofacial anomalies, and symmetrical syndactyly of the digits (cutaneous and bony fusion), has been associated with two canonical mutations in the FGFR2 gene (S252W, P253R) in the great majority of cases. Since these two alterations have been observed exclusively among these patients, it has been suggested that the S252W and P253R changes ma...

Polycomb group (PcG) genes are chromatin modifiers that mediate epigenetic silencing of target genes. PcG-mediated epigenetic silencing is implicated in embryonic development, stem cell plasticity, cell fate maintenance, cellular differentiation and cancer. However, analysis of the roles of PcG proteins in maintaining differentiation programs during vertebrate embryogenesis has been hampered du...

Treacher Collin Syndrome is a rare dominant congenital hereditary disorder. The syndrome is characterized by craniofacial deformities affecting about more than 1 in 50,000 births. Rehabilitating these patients involves a multidisciplinary approach with the prosthodontists rehabilitating various deformities involving the clinical features. This case report describes the rehabilitation of a suspe...

BACKGROUND Pneumocephalus is uncommon in craniofacial trauma and a rare occurrence in non-contact sports. It may be asymptomatic or present with signs of increased intracranial pressure and the majority of cases will resolve with conservative management. However, there should be a high index of clinical suspicion to recognise, diagnose, and manage it appropriately, as complications may be fatal...