Abstract Dietary creatine has been recently put forward as a possible intervention strategy to reduce post‐COVID‐19 fatigue syndrome yet no clinical study so far evaluated its efficacy and safety for this perplexing condition. In parallel‐group, randomized placebo‐controlled double‐blind trial, we analyzed the effects of 6‐month supplementation (4 g monohydrate per day) on various patient‐ clin...

BACKGROUND Creatine supplementation is known to exert an effect by increasing strength in high intensity and short duration exercises. There is a hypothesis which suggests that creatine supplementation may provide antioxidant activity by scavenging Reactive Oxygen Species. However, the antioxidant effect of creatine supplementation associated with resistance training has not yet been described ...

Creatine monohydrate has become the supplement of choice for many athletes striving to improve sports performance. Recent data indicate that athletes may not be using creatine as a sports performance booster per se but instead use creatine chronically as a training aid to augment intense resistance training workouts. Although several studies have evaluated the combined effects of creatine suppl...

PURPOSE The effects of creatine and exercise on chronic stress-induced depression are unclear. In the present study, we identified the effects of 4-week supplementation of creatine monohydrate and/or exercise on antidepressant behavior and raphe 5-HT expression in a chronic mild stress-induced depressed mouse model. METHODS Seven-week-old male C57BL/6 mice (n=48) were divided randomly into 5 ...

Methods In a prospective, randomized, double blind, active-comparator-controlled, parallel group pilot study, 30 male subjects, age 27.0 ± 4.6 years, with BMI of 24.75 ± 1.99 kg/m and a body surface area (BSA) of 1.953 ± 00.75 m, were randomly assigned to ingest 3 grams of creatine monohydrate (CM) in combination with isomaltulose (ISO) or dextrose (DEX) in 1 of 3 concentrations (5 gm liquid, 1...

Keywords Disease name and synonyms Excluded diseases Diagnostic criteria / definition Prevalence Clinical description Management including treatment Etiology Diagnostic methods Genetic counseling / Prenatal diagnosis Unresolved Problems References Abstract Guanidinoacetate methyltransferase (GAMT, EC 2.1.1.2) deficiency is a newly recognized inborn error of creatine synthesis. The clinical phen...

Creatine monohydrate (CrM) supplementation during resistance exercise training results in a greater increase in strength and fat-free mass than placebo. Whether this is solely due to an increase in intracellular water or whether there may be alterations in protein turnover is not clear at this point. We examined the effects of CrM supplementation on indexes of protein metabolism in young health...

PURPOSE The effects of creatine supplementation on muscle metabolism and exercise performance during a simulated endurance road race was investigated. METHODS Twelve adult male (27.3 +/- 1.0 yr, 178.6 +/- 1.4 cm, 78.0 +/- 2.5 kg, 8.9 +/- 1.1 %fat) endurance-trained (53.3 +/- 2.0 ml* kg-1* min-1, cycling ~160 km/wk) cyclists completed a simulated road race on a cycle ergometer (Lode), consisti...

Background: Skeletal muscle wasting and dysfunction are strong independent predictors of mortality in patients with chronic obstructive pulmonary disease (COPD). Creatine nutritional supplementation produces increased muscle mass and exercise performance in health. A controlled study was performed to look for similar effects in 38 patients with COPD. Methods: Thirty eight patients with COPD (me...