Objective(s): Crocin, as the main carotenoid of saffron, has shown anti-tumor activity both in vitro and in vivo. Crocin might interact with cellular proteins and modulate their functions, but the exact target of this carotenoid and the other compounds of the saffron have not been discovered yet. Microtubular proteins, as one of the most important proteins inside the cells, have several functio...

Cancer continues to represent the largest cause of mortality in the world and claims over 6 million lives each year (Abdullaev et al., 2000). An extremely promising strategy for cancer prevention today is chemoprevention, which is defined as the use of synthetic or natural agents (alone or in combination) to block the development of cancer in human beings (Abdullaev et al., 2004).It is a hotspo...

Bioreactors provide suitable conditions for the growth of cells and production secondary metabolites by regulating physical chemical factors. In this study, saffron cell crocin metabolite were evaluated in Erlenmeyer flask a stirred bioreactor. To optimize conditions, effect different concentrations 2-(N-morpholino) ethanesulfonic acid (MES) (0, 2.5 5 mM) as buffering agent sucrose (3%, 6% grad...

objective: saffron is the dried stigmas of crocus sativus l. which has various therapeutic properties in addition to its use as a spice. more than 80% of the world present production of saffron which is about 190 tons is produced in iran. to compare the quality of saffron' from different parts of the world, researcher used one sample from each country. since cultivation of saffron is done in di...

saffron or crocus sativus l. (c. sativus) has been widely used as a medicinal plant to promote human health, especially in asia. the main components of saffron are crocin, picrocrocin and safranal. the median lethal doses (ld50) of c. sativus are 200 mg/ml and 20.7 g/kg in vitro and in animal studies, respectively. saffron has been suggested to be effective in the treatment of a wide range of d...

Background: Squamous cell carcinoma (SCC) is the most common oral malignancy with high rate of mortality. Cisplatin, as effective chemotherapy drug, has side effects. Considering studies on use crocin in saffron treatment various malignancies, this study aimed at investigating effects and cisplatin their combination SCC fibroblast lines. Materials Methods: In interventional study, HN5 lines wer...

Evidence Based Medicine (EBM) is now generally perceived to be the dominant operating system in conventional medicine. It is unsurprising then that some have counseled complementary and alternative medicine practitioners to resist EBM . The efficacy of medicinal herbs does need to be established and toxicity, contraindications and side effects also need to be investigated, and this is best done...

BACKGROUND The involvement of water-soluble carotenoids, crocins, as the main and active components of Crocus sativus L. extract in learning and memory processes has been proposed. In the present study, the effect of crocins on sporadic Alzheimer's disease induced by intracerebroventricular (icv) streptozocin (STZ) in male rats was investigated. METHODS Male adult Wistar rats (n = 90 and 260-...

Objective(s) Crocin bleaching assay (CBA) is a new method for determination of antioxidant capacity. In CBA, addition of hydrogen to the conjugated double bonds of crocin results in reduction of crocin and increase in the absorbance at 440 nm, which is considered as a measure of antioxidant potential. Here CBA method was set up using di-gentiobiosyl crocin or a-crocin from Iranian saffron. The...

Context: Saffron, as a medicinal plant, is widely used to treat various diseases, especially among women. Therefore, this study was conducted review the studies on impact of saffron premenstrual syndrome (PMS), labor, childbirth, and menopause. Methods: This systematic review, based PICO process, systematically searched PubMed, Scopus, Cochrane, Embase, Web Science, Science Direct, Google Schol...