Background Ankylosing spondylitis (AS), which occurs in about 10% of inflammatory bowel disease (IBD) patients [1] , is more common Crohn’s and does not correlate with activity [2] . The occurrence IBD AS 4-16% [3-5] Objectives To investigate the patterns treatment modifications following newly diagnosed or a new diagnosis AS. Methods This retrospective observational study that included coexist...

Abstract Background Adequate infliximab (IFX) concentrations during induction treatment are predictive for deep remission (corticosteroid-free clinical and endoscopic remission) at six months in children with Crohn’s disease (CD) ulcerative colitis (UC).1 Under standard IFX dosing, often have low trough concentrations.2 Model-informed precision dosing (MIPD) is advocated as a promising strategy...

Abstract Background Subcutaneous (SC) formulations of infliximab (IFX) and vedolizumab (VDZ) were recently approved for maintenance treatment patients with inflammatory bowel disease. However, further investigation is required to identify the most likely benefit from intravenous (IV)-to-SC switch. We hypothesise that therapeutic drug monitoring (TDM) can guide IV-to-SC Methods Population pharma...

In July 2005, a 10-year-old red-faced black spider monkey (Ateles paniscus) (Figure 1) at the Artis Zoo in Amsterdam developed a disease comparable to ulcerative colitis in humans. The clinical signs included severe diarrhea, weight loss (her weight decreased from 13–8 kg in 7 months), and rectal bleeding. Blood tests showed typical signs of acute and chronic inflammation. In fecal cultures, ne...

Abstract Background Filgotinib (FIL) is a once-daily, oral, Janus kinase 1 preferential inhibitor approved for the treatment of ulcerative colitis (UC). FIL 200 mg (FIL200) was effective in inducing and maintaining clinical remission vs placebo (PBO) well tolerated patients with UC randomized, phase 2b/3 SELECTION trial (NCT02914522).1 The efficacy safety continued FIL200 therapy are being asse...

atherosclerosis is the most common cause of myocardial infarction and ischemic stroke. various risk factors have been identified for atherosclerosis. recently, bacterial and viral organisms, which are involved in chronic inflammatory processes, have been also implicated in atherosclerosis development. individuals with a prior history of periodontal diseases and/or tooth loss are considered to be...

The functional roles of transient receptor potential (TRP) channels in the gastrointestinal tract have garnered considerable attention in recent years. We previously reported that daikenchuto (TU-100), a traditional Japanese herbal medicine, increased intestinal blood flow (IBF) via adrenomedullin (ADM) release from intestinal epithelial (IE) cells (Kono T et al. J Crohns Colitis 4: 161-170, 20...

Abstract Aims 10% of emergency surgical admissions are due to acute intestinal obstruction. If surgery is required, the mortality raised 10%. The latest 2017 National Audit Small Bowel Obstruction (NASBO) has identified several key investigative and therapeutic targets. Our aim look into our clinical practice compare it NASBO standards. Methods In a district general hospital (DGH), we prospecti...