The aim of this study was to assess the impact access-site crossover in patients with acute coronary syndrome undergoing invasive management via radial or femoral access. There are limited data on clinical implications crossover. In MATRIX (Minimizing Adverse Haemorrhagic Events by Transradial Access Site and Systemic Implementation Angiox)–Access trial, 8,404 were randomized Patients successfu...

BACKGROUND Clinically significant anxiety and depression are common in patients with cancer, and are associated with poor psychiatric and medical outcomes. Historical and recent research suggests a role for psilocybin to treat cancer-related anxiety and depression. METHODS In this double-blind, placebo-controlled, crossover trial, 29 patients with cancer-related anxiety and depression were ra...

This paper brings together a variety of graphical and analytic tools used in the analysis of two-period crossover clinical trials for continuous data. SAS/GRAPH@ is used to construct exploratory analyses for carryover, period, and treatment effects. A number of different SAS@ procedures carry out various alternative inferential approaches to crossover studies. Introduction Two-period crossover ...

BACKGROUND In the Superior Yield of the New Strategy of Enoxaparin, Revascularization, and Glycoprotein IIb/IIIa Inhibitors (SYNERGY) study, patients assigned enoxaparin or unfractionated heparin (UFH) were treated with alternative anticoagulant therapy after randomization at physician discretion, a practice made possible because the trial was open label. Using SYNERGY as an example, we demonst...

BACKGROUND Pruritus (itch) is a symptom commonly experienced by patients with cholestatic liver diseases such as primary biliary cholangitis (PBC, previously referred to as primary biliary cirrhosis). Bile acids (BAs) have been proposed as potential pruritogens in PBC. The ileal bile acid transporter (IBAT) protein expressed in the distal ileum plays a key role in the enterohepatic circulation ...

Background Beta thalassemia (β-thalassemia) is one of the most common genetic disorders that reduces the amount of specific chain production in hemoglobin. The aim of this study was to compare the efficacy and safety of Desfonak with Desferal in patients with β-thalasse...

We performed a randomised controlled crossover trial of clinic letters. Structured letters were compared with conventional letters containing problem lists. There were 32 participants; 25 preferred the structured letter. Median rating and items identified were higher for the structured letter. Structured clinical correspondence with paragraph headings is strongly preferred and increases compreh...

Thirteen experienced male weightlifters taking high-protein diets and regular exercise took part in a double-blind crossover trial of methandienone 10 or 25 mg/day to seeif the drug improved athletic performance. Their improvemments were significantly greater on methandienone than on placebo; their body weights rose (though this seemed to be associated with water retention); and systolic blood...

BACKGROUND The purpose of this study was to assess the functional effects and acceptability of rocker-soled shoes that were designed to relatively "unload" the calf muscles during walking in people with calf claudication due to peripheral arterial disease. METHODS In this randomised AB/BA crossover trial, participants completed two assessment visits up to two weeks apart. At each visit, parti...

The aim of the present study was to compare the efficacy of automatic titration of noninvasive ventilation (NIV) with conventional NIV in stable neuromuscular and chest wall disorder patients established on long-term ventilatory support. In total, 20 neuromuscular and chest wall disease patients with nocturnal hypoventilation treated with long-term NIV completed a randomised crossover trial com...