Polyubiquitin chains, in which the C-terminus and a lysine side chain of successive ubiquitin molecules are linked by an isopeptide bond, function to target substrate proteins for degradation by the 26S proteasome. Chains of at least four ubiquitin moieties appear to be required for efficient recognition by the 26S proteasome, although the conformations of the polyubiquitin chains recognized by...

No. larv8536 Beamline(s): X12C, X25 Introduction: CD46, also known as membrane cofactor protein, is the cellular receptor for measles virus. The protein ectodomain consists of four concatenated “short consensus repeats” or SCR domains. Measles virus binds to domains SCR1 and SCR2, the natural ligands of CD46 (complement proteins C3b and C4b) bind to domains SCR3 and SCR4. We have recently deter...

We have determined the structure of bovine rhodopsin at 2.65 A resolution using untwinned native crystals in the space group P3(1), by molecular replacement from the 2.8 A model (1F88) solved in space group P4(1). The new structure reveals mechanistically important details unresolved previously, which are considered in the membrane context by docking the structure into a cryo-electron microscop...

In the title one-dimensional coordination polymer, [Sn(CH3)3(C8H6NO4)] n , the Sn(IV) atom is coordinated by three methyl C atoms and two carboxyl-ate O atoms (one symmetry generated), resulting in an almost regular SnC3O2 trigonal pyramid. The C atoms occupy the equatorial sites and the O atoms occupy the axial sites. In the ligand, the dihedral angles between the benzene ring and the pendant ...

Two-dimensional bidisperse foams were simulated in cyclic, uniaxial, extensional shear. Mixing of bubbles of different sizes only occurs at high strains, and once mixed, the bubbles do not segregate. For liquid fractions up to 1%, the rate of mixing is shown to be slightly enhanced by increased liquid fraction.

In the title compound, C13H13N3O, the phenyl ring makes a dihedral angle of 47.0 (1)° with the mean plane of the -NC(=O)N- unit, while the dihedral angle between the latter mean plane and the amino-phenyl ring is 84.43 (7)°. In the crystal, mol-ecules are linked via N-H⋯O hydrogen bonds involving the central -NHC(=O)NH- units, forming chains running parallel to the b axis. These chains associat...

In the title compound, C24H14BrN3S, the dihedral angles between the planes of the pyridine ring and the pendant thio-phene ring, the indole ring system (r.m.s. deviation = 0.022 Å) and the bromo-benzene ring are 9.37 (17), 21.90 (12) and 69.01 (15)°, respectively. The approximate coplanarity of the central ring and the indole ring system is supported by two intra-molecular C-H⋯N inter-actions. ...

In the title compound, C12H12N6S, the dihedral angles between the central pyrazole ring and the pendant triazole and benzene rings are 68.01 (4) and 59.83 (9)°, respectively. In the crystal, mol-ecules are linked by N-H⋯N and N-H⋯S hydrogen bonds, generating (10-1) sheets.

The ternary antimonide CeIrSb absorbs hydrogen under moderate temperature and pressure conditions (4 MPa and 573 K), leading to the hydride CeIrSbH0.8. The crystal structures of both compounds have been investigated by X-ray diffraction on powders and single crystals: TiNiSi type, space group Pnma, a = 735.07(7), b = 456.93(4), c =

In the title compound, C25H23Cl2N3, the cyclo-octene ring adopts a twist chair-chair conformation. The dihedral angles between the central pyridine ring (r.m.s. deviation = 0.013 Å) and the pendant chloro-benzene and benzyl rings are 78.07 (11) and 87.47 (12)°, respectively. No directional inter-actions could be identified in the crystal and the packing is governed by van der Waals inter-actions.