Curcumin derived from turmeric is well documented for its anti-carcinogenic, antioxidant and anti-inflammatory properties. Recent studies show that curcumin also possesses neuroprotective and cognitive-enhancing properties that may help delay or prevent neurodegenerative diseases, including Alzheimer's disease (AD). Currently, clinical diagnosis of AD is onerous, and it is primarily based on th...

The present study aims to develop and evaluate an emulgel that contains curcumin, clove oil, basil oil for the treatment of mouth ulcers. Emulgels have become a potentially effective method delivering hydrophobic medications. Menthol was used as penetration enhancer, which also provides cooling effect ulcers, whereas acts enhancer. herbal medicines such tulsi (basil) menthol very good antiulcer...

Despite the widespread use of curcumin for centuries in Eastern medicine as an anti-inflammatory agent, its molecular actions and therapeutic viability have only recently been explored. While curcumin does have potential therapeutic efficacy, both solubility and bioavailability must be improved before it can be more successfully translated to clinical care. We have previously reported a novel f...

Abstract: Aim: The main aim of present study is to formulate cubosomes containing curcumin. Curcumin a BCS class IV drug which has clinically proven good anti-bacterial property. Materials and Methods: Cubic nanoparticles were prepared by hydrotrope dilution method. Cubosomes formulated with the glyceryl monooleate pluronic F-127 as lipid surfactant respectively, obtained formulations character...

Curcumin is a natural polyphenol and essential curcuminoid derived from the rhizome of the medicinal plant Curcuma longa (L.) is universally acknowledged as "Wonder drug of life". It is a vital consumable and restorative herb, commonly keened for several ailments such as cancer, arthritis, pain, bruises, gastrointestinal quandaries, swelling and much more. Despite its enormous curative potentia...

To improve the bioavailability of orally administered lipophilic coenzyme Q10 (CoQ10), we formulated a novel lipid-free nano-CoQ10 system stabilized by various surfactants. Nano-CoQ10s, composed of 2.5% (w/w) CoQ10, 1.67% (w/w) surfactant, and 41.67% (w/w) glycerol, were prepared by hot high-pressure homogenization. The resulting formulations were characterized by particle size, zeta potential,...

The aim of this study was to enhance the transdermal delivery of Sildenafil Citrate by encapsulation in nano sized ultra deformable vesicles, transfersomes. The thin film hydration and sonication technique was utilized in the preparation of Sildenafil Citrate loaded Transfersomes and both non ionic and ionic edge activators (anionic and cationic) were used in varying ratios to study their effec...

Anaplasma marginale is the most prevalent tick-borne livestock pathogen and poses a significant threat to cattle industry. In contrast to currently available live blood-derived vaccines against A. marginale, alternative safer and better-defined subunit vaccines will be of great significance. Two proteins (VirB9-1 and VirB9-2) from the Type IV secretion system of A. marginale have been shown to ...

Migraine is a chronic nerves system disease leads to considerable disabilities and affected quality of life. Neuro-inflammation play a key role in progression of migraine which mainly caused by release of inflammatory mediators including COX-2 and iNOs enzymes, TNF-α،IL-1β،IL-6 and adhesion molecule such as ICAM and VCAM.Curcumin and omega 3 fatty acids with anti-inflammatory and neuro-protecti...