Cutaneous γ/δ T-cell lymphoma is an extremely rare and highly aggressive tumor that is often resistant to treatment, such as polychemotherapy and radiotherapy. Due to the complexity of clinical, pathologic, and immunohistochemical features of this disease entity, the physician should perform a careful evaluation; however, treatment should be rapid and aggressive. We present a case of fatal cuta...

Primary cutaneous CD8+ small/medium-sized pleomorphic T-cell lymphoma (CD8+ SMPTL) is a rare entity with most probably indolent clinical behaviour. Several cases with facial localisation, mostly localised to the ear, have previously been described (1). Reports of extrafacial involvement are limited, and mostly involve acral sites such as the hands and feet. The classification concerning this ra...

Primary cutaneous CD4 positive small/medium T cell lymphoma (PCSM-TCL) is a provisional entity in the new WHO-EORTC classification for cutaneous lymphoma, and it is a rare disease with a favorable clinical course. PCSM-TCL may present with different clinical and pathologic features associated with the biologic behavior of the disease. Herein we report on a 63-year-old woman with multiple, multi...

Primary cutaneous lymphomas can be difficult to be distinguished from reactive mimics, even when integrating histologic, immunophenotypic, and clinical findings. Molecular studies, especially PCR-based antigen receptor gene rearrangement (ARGR) analysis, are frequently useful ancillary studies in the evaluation of cutaneous lymphoproliferations. The biologic basis of ARGR studies is discussed, ...

Mucin 1 (MUC1), a member of the mucin family, is a highly glycosylated transmembrane protein normally present on the luminal surface of secretory glands (1). Overexpression of MUC1 in tumour cells and elevated serum MUC1 level have been reported in patients with cutaneous T-cell lymphoma (CTCL) (2, 3). We report here a patient with increased serum MUC1 level and aberrant MUC1 expression in the ...

Background: Primary cutaneous T cell lymphoma is a diverse and rare group of diseases with clinical manifestations that, if not biopsied, are easily confused benign skin diseases. Objective: To determine some features primary lymphomas classify them according to the 2018 update World Health Organization European Organisation for Research Treatment Cancer classification. Methods: case series stu...

This chapter describes the various ways in which the non-Hodgkin's lymphomas can involve the skin, how these diseases should be assessed, standard treatments available in 2002, and new directions in research. The goal of the session is to succinctly review recent developments in lymphoma classification and treatment as they apply to the unique aspects of lymphoma when manifest in the skin. In S...

INTRODUCTION Mycosis fungoides, the most common type of cutaneous T-cell lymphoma, can manifest in a variety of clinical and histological forms. Bulla formation is an uncommon finding in mycosis fungoides and only approximately 20 cases have been reported in the literature. CASE PRESENTATION We present a case of rapidly progressive mycosis fungoides in a 68-year-old Caucasian man who initiall...

Whether parapsoriasis represents an early stage of T-cell cutaneous lymphoma is still the subject of controversy. We evaluated the efficacy of phototherapy in the treatment of parapsoriasis and its relation with TCCL. Patients diagnosed with parapsoriasis and treated with phototherapy PUVA or UVB-NB were selected. Between 1 to 8 years following treatment the evolution of their disease was evalu...

Primary cutaneous lymphomas (PCLs) are defined as non-Hodgkin lymphomas that present in the skin with no evidence of extracutaneous disease at the time of diagnosis. After the gastrointestinal lymphomas, PCLs are the second most common group of extranodal non-Hodgkin lymphomas with an estimated annual incidence of 1/100 000. PCL must be distinguished from nodal or systemic malignant lymphomas i...