Polyarteritis Nodosa (PAN) is a vasculitis of unknown origin that affects the medium and small arteries of our organ system. Isolated Polyarteritis Nodosa is a rare condition that may be due to modulation of local immune reaction by exposure to certain local triggering agent without any systemic immune reaction. Symptomatic PAN confined to the testis in hepatitis B infection is extremely rare a...

A 37-year-old Chinese male presented with an acute abdomen. Surgical exploration revealed duodenal perforation, extensive small bowel infarction and peritonitis. Histopathology of the resected bowel showed characteristic features of classic polyarteritis nodosa. The latter also involved mesenteric arteries in the form of tiny aneurysms. Steroids could not be started due to: (i) overwhelming mic...

sions. Moreover, our patient could be differentiated from papular acne scars, white fibrous papulosis of the neck and morphea guttate. The histological features of all of these diseases are distinct from those of PE. There is no consensus whether PE is a unique entity or just a special demonstration of nevus anesticus, eruptive collagenoma and a mild form of Buschke-Ollendorff syndrome [6]. We ...

A rare case of polyangiitis overlap syndrome is described. The patient was a 25-year-old man who had palpable purpura on his legs which showed leukocytoclastic vasculitis, and polyarteritis nodosa. Superior mesenteric arteriography showed microaneurysms in jejunal branches with focal segmental necrotizing arteritis of small and medium sized muscular arteries in the jejunum. Deposits of IgA and ...

We describe the effect of interleukin 6 (IL-6) blockade using tocilizumab (TCZ) for inducing and maintaining remission of refractory polyarteritis nodosa (PAN). Three patients with refractory PAN defined according to the American College of Rheumatology criteria were treated with TCZ infusions (8 mg/kg) on a monthly basis. All of them had severe cutaneous and articular involvement with elevated...

Arthritis has been reported as an acute pattern, generally evanescent with oligoarthritis, mostly affecting knees and ankles in childhood systemic polyarteritis nodosa. However, chronic polyarthritis with morning stiffness mimicking juvenile idiopathic arthritis has not been reported. We describe the case of a 4-year old girl who had additive and chronic polyarthritis with edema, tenderness, pa...

Polyarteritis nodosa was first described as a clinico-pathological entity by Kussmaul and Maier ( 1866), who called it periarteritis nodosa. Ferrari (1903) first called the disease polyarteritis nodosa, a name that describes the pathology more accurately. The disease may be grouped with the collagen diseases-desseminated lupus erythematosis, scleroderma, rheumatoid arthritis and others. It is c...

In a young woman, the differential diagnosis of ulcerated skin lesions on the lower limbs that heal leaving atrophic scars should include vasculitis and occlusive vasculopathy. Cutaneous polyarteritis nodosa (CPN) is characterized by the presence of painful nodules that typically develop on the lower limbs, frequently ulcerate, and usually heal without residual hyperpigmentation. Its diagnosis ...