The cyclodextrin capacity to form inclusion complexes is known for a long time, this property being used in textile industry to obtain products with applications in increasing wear comfort and realization of medical textiles. Yet, there is always the possibility to find new applications of these complexes, either by their permanent fixation on textiles, or by making them environmentally friendl...

Purpose: Development and physicochemical characterisation of eudermic submicron emulsions (SE) based on natural surfactants (lecithin, sucrose stearate) with different cyclodextrins as co-stabilising agents. Methods: Positively and negatively charged SE are prepared by high pressure homogenisation technique [1]. Particle size and zeta potential are determined by dynamic light scattering. Long-t...

Melarsoprol, a water-insoluble drug, is mainly used in the treatment of trypanosomiasis and has demonstrated an in vitro activity on myeloid and lymphoid leukemia derived cell lines. It is marketed as a very poorly tolerated non-aqueous solution (Arsobal). The aim of our work was to develop melarsoprol-cyclodextrin complexes in order to improve the tolerability and the bioavailability of melars...

Cyclodextrins are useful functional excipients that have enjoyed widespread attention and use. The basis for this popularity from a pharmaceutical standpoint, is the ability of these materials to interact with poorly water-soluble drugs and drug candidates resulting in an increase in their apparent water solubility. The mechanism for this solubilization is rooted in the ability of cyclodextrin ...

Abstract Cyclodextrins are widely used in various fields including food industry. In this review, their role high carbohydrate-containing, starchy foods reviewed and discussed. Both the effects as functional ingredients affecting structural properties of starch active slowing down digestion and, a consequence, decreasing glycaemic index overviewed without considering traditional applications ca...

Cyclodextrin glucanotransferase (CGTase, EC 2.4.1.19) is an important member of α-amylase family which can degrade the starch and produce cyclodextrins (CDs) as a result of intramolecular transglycosylation (cyclization). β-Cyclodextrin production was carried out using the purified CGTase enzyme from an alkaliphile Microbacterium terrae KNR 9 with different starches in raw as well as gelatinize...

Thermoanaerobacterium thermosulfurigenes cyclodextrin glucanotransferase primarily catalyses the formation of cyclic alpha-(1,4)-linked oligosaccharides (cyclodextrins) from starch. This enzyme also possesses unusually high hydrolytic activity as a side reaction, thought to be due to partial retention of ancestral enzyme function. This side reaction is undesirable, since it produces short sacch...

The knowledge of the host-guest complexes using cyclodextrins (CDs) has prompted an increase in the development of new formulations. The capacity of these organic host structures of including guest within their hydrophobic cavities, improves physicochemical properties of the guest. In the case of pesticides, several inclusion complexes with cyclodextrins have been reported. However, in order to...

A variety of cyclodextrin-based molecular structures, with substitutions of either primary or secondary faces of the natural oligosaccharide macrocycles of α-, β-, or γ-cyclodextrins, have been designed towards innovative applications of self-assembled cyclodextrin nanomaterials. Amphiphilic cyclodextrins have been obtained by chemical or enzymatic modifications of their macrocycles using phosp...