UNLABELLED BACKGROUND Thromboxane A2 is derived from arachidonic acid through the action of cyclooxygenases and thromboxane synthase. It is mainly formed in blood platelets upon activation and plays an important role in aggregation. Aspirin is effective in reducing the incidence of complications following acute coronary syndrome and stroke. The anti-thrombotic effect of aspirin is obtained t...

Paracetamol, one of the most widely used pain-relieving drugs, is deacetylated to 4-aminophenol (4-AP) that undergoes fatty acid amide hydrolase (FAAH)-dependent biotransformation into N-arachidonoylphenolamine (AM404), which mediates TRPV1-dependent antinociception in brain rodents. However, paracetamol also converted liver-toxic metabolite N-acetyl-p-benzoquinone imine already at therapeutic ...

Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most widely used therapeutics against pain, fever, and inflammation; additionally, antitumor properties reported. NSAIDs reduce synthesis of prostaglandins by inhibiting cyclooxygenase (COX) isoforms COX-1 COX-2. As nonselective inhibition is associated with off-target effects, strategies to achieve selectivity for clinically preferred isofo...

The purpose was to investigate effect of edible bird's nest (EBN) on the immunological properties mice with lung injury induced by sulfur dioxide (SO2). In mice, SO2 exposure caused symptoms that included a cough, tiredness, and weight loss. Administering EBN improved function in dose-dependent manner, leading recovery tissue increasing thymus spleen indices. IL-2 IFN-γ serum Th1 cells response...

Cyclooxygenase and 5-lipoxygenase are enzymes that catalyze important inflammatory pathways, suggesting that dual cyclooxygenase/lipoxygenase inhibitors should be more efficacious as anti-inflammatory medicines with lower side effects than the currently available nonsteroidal anti-inflammatory drugs. Many plants from the family Asteraceae have anti-inflammatory activities, which could be exerte...

In vivo studies have shown that inhibitors of cyclooxygenase metabolism of arachidonic acid may diminish growth and metastasis of certain tumors. Because cyclooxygenase inhibition may increase the production of lipoxygenase products of arachidonic acid metabolism, we have investigated the effect of two such products, 12-hydroxyeicosatetraenoic acid (12-HETE) and 15-hydroxyeicosatetraenoic acid ...

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used in pain whose mechanism of action is the inhibition cyclooxygenase enzymes (COXs), however, there evidence other mechanisms action, such as substance P, interaction with systems NO, monoaminergic and others. The objective present work was to study participation a-1 (prazosin) a-2 (yohimbine) adrenoceptors antagonists antinociception...

cyclooxygenase-2 (cox-2) has a pivotal role in the pathogenesis of the lung cancer. it is known that cox-2 negatively regulates the activity of a number of tumor suppressors, including p53. consequently, inhibition of cox-2 signaling is anticipated to be a promising approach to stabilize p53 functionality. in this regard, we investigated the effect of cox-2 signaling blockade on p53 and cox-2 e...