Interferon- gamma (IFN- gamma) is an important immune regulator and inflammatory cytokine which is implicated in the pathogenesis of multiple sclerosis (MS). A single nucleotide polymorphism, T to A, at position +874 in the first intron has previously been shown. This polymorphism is associated with IFN- gamma production level. To study the effect of this polymorphism on susceptibility to multi...

results mean urinary il-1α, il-4, il-6, and il-8 concentrations significantly increased in the acute phase of apn compared to the control group, and decreased following antibiotic treatment. conclusions we recommend routine urinalysis and urine culture for the diagnosis of children with apn. urinary il-4 was a relatively good cytokine for the prediction and treatment-monitoring of children with...

Schizophrenia is a chronic mental disorder that caused by complex palette of genetic, epigenetic and environmental factors. Some the important components its pathogenesis are systemic inflammation dysfunction immunity, which lead to neuroinflammation, contributing development structural brain changes. Earlier we have shown increase in interleukin-17A levels associated with morphometric changes ...

Introduction: Haemophilia A (HA) is an inherited X-chromosome recessive disorder characterized by the deficiency of factor VIII (FVIII). About 25-30% HA patients which received FVIII concentrate developed inhibitors towards FVIII. Ethnicity has been associated as a predisposing for formation inhibitors. This study characterizes polymorphism +49A/G and -318C/T Cytotoxic T-Lymphocytes Antigen 4 (...

conclusions the current study adds evidence to the association of tnf-α gene polymorphism and ms in this southern south iranian population which is consistent with the genetic analysis of ms in europeans (games) project reports and these two alleles reported in this study may be one of the genetic risk factor for ms. furthermore, this data can be used to build the iranian gene bank for future s...