Different acid chlorides (2a-d) reacted with anthranilic acid to produce 2-substituted-3, 1-benzoxazin-4-one (3a-d) which was used as starting material to synthesize some condensed and non-condensed heterocyclic compounds by reaction with nitrogen nucleophiles e.g., hydrazine hydrate, and formamide. Some of the newly synthesized analogues were chosen to evaluate their cytotoxic activity against...

Different acid chlorides (2a-d) reacted with anthranilic acid to produce 2-substituted-3, 1-benzoxazin-4-one (3a-d) which was used as starting material to synthesize some condensed and non-condensed heterocyclic compounds by reaction with nitrogen nucleophiles e.g., hydrazine hydrate, and formamide. Some of the newly synthesized analogues were chosen to evaluate their cytotoxic activity against...

cancers belong to a group of disorders which are very important for researchers.  because they have several types and cause mortality in human beings. many  investigations are performing in order to introduce cheaper drugs with lower side  effects especially with natural sources. ferula genus grows all over the world but  some of them are endemic to iran. many investigations have proved differe...

tribulus terrestris (tt) is a member of the zygophyllaceae family. traditional chinese medicine recommends the use of tt for treatment of a variety of diseases. in the present study we further investigated anti-proliferative and cytotoxic effects of tt extract on normal and several malignant cell lines. for this purpose, ttwas collected and after authentication, aqueous extract was prepared. cy...

cancer is a group of diseases characterized by uncontrolled proliferation of abnormal cells. because of the severe side effects and resistance to the traditional chemotherapeutic agents, the necessity for discovery of new anticancer drugs is a crucial topic. in the present study we synthesized new derivatives of 2-(4-fluorophenyl)- n -halophenylacetamide and assessed their cytotoxicity against ...

Although Mycobacterium ulcerans elicits extensive necrosis of human skin and subcutaneous tissue, the specific cause of the necrosis has never been elucidated. In an attempt to define a toxic substance, 18 strains of M. ulcerans were inoculated into mice, and the progress of each infection was observed and compared with infections of other mycobacteria, including M. cheloni, M. marinum, and M. ...

two flavones, ladanein and 6-hydroxy-5,7,4′-trimethoxyflavone and one labdane-typediterpene, ent-13-epi-manoyloxide, were isolated from an ethyl acetate-methanol extract ofthe aerial parts of salvia sharifii. the compounds were purified using several chromatographicmethods. structural elucidation of the compounds was performed using their 1h and 13c-nmrdata, ei mass and uv spectral data. the co...

A microelectronic sensor-based platform, the RT-CES (real time electronic sensing) system, is introduced for label free assessment of natural killer (NK) cell-mediated cytotoxic activity. The RT-CES system was used to dynamically and quantitatively monitor NK-mediated cytotoxic activity towards 8 different adherent target cell lines, including cancer cell lines commonly used in laboratories. Th...

A whole variety of chemical and biological materials have immunosuppressive effects in animals. Although anti-inflammatory agents, especially the corticosteroids, are inhibitors of the immune response, most are general cytotoxic agents. The cytotoxic agents were first developed as antitumour agents. It is now well known that they are not particularly selective for cancer cells, but are selectiv...

Cutaneous leishmaniasis (CL) is a chronic disease caused by species of the protozoan Leishmania and characterised by the presence of ulcerated skin lesions. Both parasite and host factors affect the clinical presentation of the disease. The development of skin ulcers in CL is associated with an inflammatory response mediated by cells that control parasite growth but also contribute to pathogene...