1,2-Dioxolanes and 1,2-dioxanes are 5- 6-membered peroxidized heterocycles. They constitute relatively stable endoperoxide, which can be found over more than 400 isolated natural products. A major part of endoperoxides contains a 1,2-dioxane scaffold, was from marine species, notably sponges, but also present in plant or mushrooms for instance. Because these compounds exhibit potential cytotoxi...

The 2-pyrone moiety can be found in a large number of natural products with wide range biological activities, including antibiotic, antifungal, cytotoxic, neurotoxic, phytotoxic, anti-inflammatory and cardiotonic effects. With its heterocyclic structure encompassing the chemical nature conjugated dienes, lactones, Michael acceptors arenes, it undergo great variety transformations such as cycloa...

It is known that some plant polyphenols and alkaloids can act as effective photosensitisers of UV radiation. This phenomenon enhance both therapeutic side effects. Since there no information regarding curcuminoids on their ability to function photosensitisers, this work investigated the effect radiation cytotoxic curcumin, well its nanostructured forms, against keratinocytes HaCaT line cancer c...

AIM To study preventive effect of cytotoxic lectin from Bacillus subtilis B-7025 on the tumor growth and nonspecific immunity in sarcoma 37 transplanted mice. METHODS Sarcoma 37 cells were transplanted in Balb/c mice. Cytotoxic lectin (CL) was isolated from cultural fluid of B.subtilis strain B-7025 and inoculated at a dose of 0.2 mg per animal in prophylactic or combined schedule. Functional...

Introduction: Spontaneous reporting of adverse drug reactions is the basis pharmacovigilance, main objective which to ensure safe use drugs, particularly cytotoxics, through continuous monitoring events caused by them. The aims this study were investigate perception nurses towards and identify reasons for under-reporting cytotoxic drugs in Morocco. Methods: Individual semi-structured interviews...

objective(s): nowadays, cancer is an important public health problem in all countries. limitations of current chemotherapy for neoplastic diseases such as severe adverse reactions and tumor resistance to the chemotherapeutic drugs have been led to a temptation for focusing on the discovery and development of new compounds with potential anticancer activity.   materials and methods: a new series...

Contact hypersensitivity (CHS) is a T cell-mediated skin inflammation induced by epicutaneous exposure to haptens in sensitized individuals. We have previously reported that CHS to dinitrofluorobenzene in mice is mediated by major histocompatibility complex (MHC) class I-restricted CD8(+) T cells. In this study, we show that CD8(+) T cells mediate the skin inflammation through their cytotoxic a...

Panax ginseng has long been used in Asia as a herbal medicine for the prevention and treatment of various diseases, including cancer. The current study evaluated the cytotoxic potency against a variety of cancer cells by using ginseng ethanol extracts (RSE), protopanaxadiol (PPD)-type, protopanaxatriol (PPT)-type ginsenosides fractions, and their hydrolysates, which were prepared by stepwise hy...

The cyclometalated acetate ruthenium complexes [Ru(C^N)(η2-OAc)(dppb)] (dppb = 1,4-bis(diphenylphosphino)butane; HC^N 2-phenylpyridine 1, benzo[h]quinoline 2, 1-phenylpyrazole 3, 2-phenyl-2-oxazoline 4) are easily obtained in 58-74% yield through a one-pot synthesis from...