نتایج جستجو برای: damage accumulation
تعداد نتایج: 366832 فیلتر نتایج به سال:
We consider a phenomenological model for bone remodeling, proposed by Hazelwood et al. [1], which represents the process through a coupled population equation for basic multicellular units (BMU) and a rate equation for microdamage. Its fundamental dependence on empirical data can lead to unbalanced model terms making any numerical approximations sensitive to implementation error. Thus we propos...
Here we report that RNA interference against ATM inhibited p53 accumulation in cells expressing oncogenic STAT5 and cooperated with Rb inactivation to suppress STAT5A-induced senescence. Knocking down ATM was also effective to bypass E2F1-induced senescence and in combination with Rb inactivation, inhibited RasV12-induced senescence. Cells that senesced in response to ca-STAT5A or RasV12 accumu...
Platelet (P-) selectin and intercellular adhesion molecule-1 (ICAM-1) mediate accumulation of neutrophils in brain. However, the mechanisms regulating neutrophil accumulation and damage after traumatic brain injury (TBI) are poorly defined. We hypothesized that mice deficient in both P-selectin and ICAM-1 (-/-) would have decreased brain neutrophil accumulation and edema, and improved functiona...
The DNA damage response (DDR) plays a pivotal role in maintaining genome integrity. DNA damage and DDR activation are observed in the failing heart, however, the type of DNA damage and its role in the pathogenesis of heart failure remain elusive. Here we show the critical role of DNA single-strand break (SSB) in the pathogenesis of pressure overload-induced heart failure. Accumulation of unrepa...
delaying bud break, using chemicals is an approach to avoid spring frost damage. therefore, the effect of spraying different concentrations of soybean oil and naphthalene acetic acid (naa) on delaying bud break, altering internal atmosphere and cold hardiness in grape cultivar ‘fakhri’ was studied in 2011 in a commercial vineyard in maryanaj, hamedan using a factorial trial based on randomized ...
Analytical models that predict modulus degradation in cortical bone subjected to uniaxial fatigue loading in tension and compression are presented. On the basis of experimental observations, damage was modeled as self-limiting for tension but not for compression. These mechanistic uniaxial damage models were then developed into a model for flexural fatigue of cortical bone based on laminated be...
The development of grain-boundary cavitation in hot-pressed A1203 both during flexural creep and tress-free annealing in air has been studied. Creep damage accumulation in driven both by the applied stress, and by internal gas pressure in the cavities. The internal pressure results from gas trapped during hot pressing, and from gas-generating chemical reactions active during testing. At machine...
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