objective: mitochondrial dna (mtdna) is a useful tool for population studies, identification of humans and forensic dna studies. the existence of several hundreds copies of mtdna per cell permit its extraction from minute or degraded samples. in addition, the level of polymorphism in the hypervariable (hv) region is high enough to permit its use in human identity testing. however, the presence ...

Replicative aging in yeast is asymmetric-mother cells age but their daughter cells are rejuvenated. Here we identify an asymmetry in pH between mother and daughter cells that underlies aging and rejuvenation. Cytosolic pH increases in aging mother cells, but is more acidic in daughter cells. This is due to the asymmetric distribution of the major regulator of cytosolic pH, the plasma membrane p...

From an evolutionary perspective, matriliny presents a puzzle because men in matrilineal societies transmit wealth to their sisters’ sons, to whom they are only half as related as to their own sons. It has been argued that such systems would only maximise fitness under unrealistically high levels of paternity uncertainty. In this paper, we propose that matriliny can arise from daughterbiased in...

The processes for repairing DNA daughter-strand gaps were studied in UV-irradiated uvrB, uvrB recB, uvrB recF, and uvrB recB recF cells of Escherichia coli K-12. The dimer-containing parental DNA was found to be joined to daughter strands during postreplication repair in all four strains examined. Therefore, both the major (recF-dependent) and the minor (recF recB-independent) gap-filling proce...

Abstract In Ogihara’s edition of the Tocharian B so-called “Avadāna-Manuscript”, a fragment from Dhanika-Avadāna contains word santse. On basis parallel texts, it is shown that santse means ‘daughter-in-law’. This newly identified cognate with a.o. Greek νυός ‘daughter-in-law’ and derives Proto-Indo- European *snusó-.

Loving science and nature and being a scientist can be very different, yet the two are so intertwined in a scientist's life that you will certainly experience both aspects. This essay presents my perspective on how, as one who loves science and nature, I came to fall in love with centrosome behavior in stem cells and how I came to run a lab as a scientist. When I started, there was a big gap be...

Five patients with hepatic (3), pelvic (1) or spinal (1) hydatid cysts received 10 mg/kg/d albendazole for 1-3 months prior to surgery. Daughter cysts were present in the spinal hydatid and in one patient with hepatic disease. Electron microscope examination of the cyst tissue of the pelvic and the 2 hepatic cysts lacking daughter cysts showed no evidence of germinal layer, and the protoscolece...