نتایج جستجو برای: daunorubicin

تعداد نتایج: 2644  

2013
Daniela Cihalova Jakub Hofman Martina Ceckova Frantisek Staud

Cyclin-dependent kinase inhibitors (CDKi) have high potential applicability in anticancer therapy, but various aspects of their pharmacokinetics, especially their interactions with drug efflux transporters, have not yet been evaluated in detail. Thus, we investigated interactions of five CDKi (purvalanol A, olomoucine II, roscovitine, flavopiridol and SNS-032) with the ABCB1 transporter. Four o...

2015
Qiang Gong Lixin Zhou Shuangnian Xu Xi Li Yunding Zou Jieping Chen Ken Mills

The right dose of daunorubicin (DNR) for the treatment of newly diagnosed acute myeloid leukemia (AML) is uncertain. Previous trials have shown conflicting results concerning the efficacy of high or low doses of daunorubicin to induction chemotherapy for newly diagnosed AML. A systematic review and meta-analysis was conducted to resolve this controversial issue. We compared the efficacy and saf...

Journal: :FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1997
V Mansat A Bettaïeb T Levade G Laurent J P Jaffrézou

To address the role of a plausible protease cascade in daunorubicin-triggered apoptosis, we evaluated the effect of cell-permeant protease inhibitors on its signal transduction pathway. Treatment of U937 and HL-60 cells with 0.5-1 microM of the chemotherapeutic drug daunorubicin induced a greater than 30% activation of neutral sphingomyelinase activity within 4-10 min with concomitant sphingomy...

Journal: :American journal of physiology. Cell physiology 2007
Dong Fu Basil D Roufogalis

Intracellular traffic of human P-glycoprotein (P-gp), a membrane transporter responsible for multidrug resistance in cancer chemotherapy, was investigated using a P-gp and enhanced green fluorescent fusion protein (P-gp-EGFP) in human breast cancer MCF-7 cells. The stably expressed P-gp-EGFP from a clonal cell population was functional as a drug efflux pump, as demonstrated by the inhibition of...

Journal: :Annals of oncology : official journal of the European Society for Medical Oncology 2001
J P Steele C A O'Doherty J Shamash M T Evans N H Gower M D Tischkowitz R M Rudd

BACKGROUND To assess the response rate, toxicity and survival in patients with malignant pleural mesothelioma treated with liposomal daunorubicin. The study design allowed for dose escalation pending toxicity. PATIENTS AND METHODS Liposomal daunorubicin (DaunoXome, Nexstar, USA) 120 mg/m2 was administered every 21 days to a maximum of 6 cycles. Patients had to have histologically-proven malig...

2015
Mihail Kamburov Margarita Simeonova

The present study deals with the preparation and characterization of chitosan microparticles as a drug delivery system for daunorubicin. The microparticles are prepared by the suspension method and their properties are improved by covalent crosslinking using glutaraldehyde. The obtained spherical microparticles with size of 300 μm are loaded with daunorubicin. The мorphology and chemical compos...

Journal: :International Journal of Nanomedicine 2007
Christin E Petre Dirk P Dittmer

Anthracycline compounds including daunorubicin are the foundation of many modem chemotherapeutic regimens. However, the side-effects of these compounds can be severe, leading to alopecia, nausea, immune deficiency, and cardiotoxicity. For immunocompromised patients with aggressive Kaposi's sarcoma (KS), these complications often preclude the completion of appropriate chemotherapeutic regimens. ...

Journal: :Annals of oncology : official journal of the European Society for Medical Oncology 2001
A Tulpule M U Rarick J Kolitz J Bernstein A Myers L A Buchanan B M Espina A Traynor J Letzer G R Justice D McDonald L Roberts W Boswell B Nathwani A M Levine

PURPOSE To assess the efficacy and toxicity of liposomal daunorubicin administered as a two-hour intravenous infusion to patients with relapsed or refractory non-Hodgkin's lymphoma (NHL). PATIENTS AND METHODS Eligible patients had relapsed or refractory NHL with measurable or evaluable disease, and low grade, select intermediate grade, or mantle cell pathologic types. Prior exposure to an ant...

Journal: :Turkish neurosurgery 2016
Emin Vural Murat Yilmaz Konuralp Ilbay Gül Ilbay

AIM Epineural adhesion after peripheral nerve surgery is common. The purpose of this study was to evaluate the macroscopic and histopathologic effects of topical mitomycin C and daunorubicin on epineural scar formation. MATERIAL AND METHODS In this study, we used 15 rats (30 nerves). Two test groups and one control group were created. Sciatic nerve exposure was created bilaterally in each gro...

2006
Craig Munger Amy Ellis Karen Woods Joyce Randolph Saul Yanovich David Gewirtz

The H-35 rat hepatoma is relatively insensitive to the anthracycline antibiotic, daunorubicin (DNR), requiring 0.25 MMdaunorubicin for in hibition of cell proliferation by 50%. Studies were undertaken to inves tigate the basis for the apparent intrinsic resistance in this cell line. The relative insensitivity of the H-35 cells to DNR is not a function of metabolic inactivation of DNR to deoxyag...

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