An in vivo test study to prove its effectiveness as an antihyperuricemia requires animal model with a hyperuricemic condition. Foods that contain high purine bases have the potential increase uric acid levels blood, including chicken liver and melinjo seeds. This aims determine of combination juice seed powder producing hyperuricemia conditions most optimal onset duration rats vivo. Six groups ...

background: faba bean toxicity (favism) is a common condition observed in our region.   objective : to develop a short and simple technique involving the use of riboflavin-deficient rats to test in vivo faba bean toxicity.   methods/results: sprague dawley rats were maintained on a riboflavin-deficient diet and their vitamin b 2 status was monitored by the assay of erythrocyte glutathione reduc...

BACKGROUND: Cisplatin is one of the most potent chemotherapy drugs to treat various types cancer, however use cisplatin has some adverse effect, such as increase oxidative stress and inflammation by malondialdehyde (MDA) nuclear factor kappa B (NF-kB) activation. Since dosing critical, we observed effect single multiple doses injection on rats’ level.METHODS: Total 27 male Sprague-Dawley rats w...

Abstract Purpose Currently, diabetes and the consequent DN are considered a major public health issue. However, mechanism of its treatment require further clarification. This study proposed noninvasive T1-weighted (T1W) T2-weighted (T2W) MRI protocols for longitudinal assessment kidney disease progression after induction in Sprague Dawley (SD) rats. Methods The changes image indices over time b...

Background: Acute pancreatitis (AP) is a typical destructive inflammation of the pancreas. The direct effect L. wallichii on AP remains unknown.Methods: animal model was constructed by intraperitoneal injection caerulein in male Sprague–Dawley rats. extracts were used to treat rats with AP. Then, tissue injury evaluated hematoxylin and eosin staining. Serum indicators, including amylase, lipase...

Lifestyle associated disorders have always been a hazard for the advancement of chronic diseases. Therefore, use natural dietary sources is proved to be safe reducing occurrence and management Okra along with its various parts has used treatment several The present study was done examine ameliorating effect okra seed oil on hypercholesterolemic rats. Spargue Dawley Rats were randomly divided in...

Abstract: Introduction: Periplaneta americana (P. americana), commonly known as the American cockroach, has shown multiple clinical benefits. Small Peptides from P. (SPPA) was found to have promising antioxidative effects in vitro. However, pharmacological benefits of SPPA demand further in-depth investigation underlying mechanism for its effect remain unexplored. Objectives: To evaluate on ova...

Several indices of sexual behavior were characterized for male rats of the Lewis (LEW), Sprague-Dawley (SD) and Fischer (F344) strains. Males were permitted access to a receptive female of their own strain for five 50-min sessions every fifth day. LEW males emitted longer latencies (first mount, intromission, ejaculation and post-ejaculatory interval) and lower frequencies (mounts, intromission...