Over the last decade, deep brain stimulation (DBS) has revolutionized the treatment of movementdisorders and is now being used experimentally to treat refractory psychiatric disorders as well. DBS is a neurosurgical treatment involving the implantation of electrodes, which send electricity to specific targets deep in the brain. DBS in psychiatric disorders such as Tourette syndrome (TS), obsess...

BACKGROUND Subthalamic nucleus deep brain stimulation is effective in reducing motor symptoms in appropriately selected patients with Parkinson's disease. We identified factors that contribute to poor outcomes during early, middle and late stages of stimulation management in a series of patients that were referred for troubleshooting poor outcomes. METHODS We performed a retrospective review ...

BACKGROUND Parkinson's disease is accompanied by deficits in passive motion and limb position sense. OBJECTIVE To investigate whether deep brain stimulation of the subthalamic nucleus (STN-DBS) reverses these proprioceptive deficits. METHODS AND RESULTS A passive movement task was applied to nine patients with Parkinson's disease and bilateral chronic STN-DBS and to seven controls. Threshol...

The effects of subthalamic nucleus (STN) deep brain stimulation (DBS) in Parkinson's disease (PD) on different language abilities are still controversial and its impact on high-level language abilities such as metaphor comprehension has been overlooked. The aim of this study was to determine the effects of STN electrical stimulation on metaphor comprehension and language abilities such as lexic...

Abstract Background: To personalize deep brain stimulation (DBS), we need to identify a link between DBS parameters and the neural response of an individual. The existing approach based on random or empirical sampling (RS) is time-consuming, costly, practically impossible in clinical setting. This limits discovery novel settings under challenging situations. address this problem, have developed...

BACKGROUND Leva-dopa (L-dopa) is the gold-standard treatment for Parkinson's disease (PD). Deep brain stimulation is generally reserved for patients who become refractory to l-dopa treatment. CASE DESCRIPTION We present a male patient with a 9-year course of PD who at 53 years of age preferred deep brain stimulation (DBS) of the subthalamic nucleus over initial l-dopa treatment. The patient a...

Introduction: Parkinson’s disease is one of the most disabling diseases which by electrode implantation and stimulation of subthalamic nucleus (STN), much progress has been made in the treatment of drug resistant patient. This new method of neurosurgery may have some neuropsychological side effects on the patients. The main aim of this study is to evaluate the effects of this kind of treatment ...

Although locating the stimulation contact in Deep Brain Stimulation (DBS) requires a sub-mm-precision, it remains a trial-and-error, patient-specific procedure that is usually the main cause of post-operational side-effects. In this work, we used microelectrode recordings from Parkinson’s disease (PD) patients, acquired at the Neurosurgery Clinic, Evangelismos Hospital, Athens, Greece, to relat...

OBJECTIVE Tourette's syndrome (TS) is defined by 1 year of persistent motor and vocal tics. Often, the tics are refractory to conventional pharmacologic and psychobehavioral interventions. In these patients, deep brain stimulation (DBS) may be an appropriate intervention. This paper reviews different DBS targets in TS, discusses existing evidence on the efficacy of DBS in TS, highlights adverse...

UNLABELLED Noninvasive brain stimulation studies have shown abnormal motor cortical plasticity in Parkinson's disease (PD). These studies used peripheral nerve stimulation paired with transcranial magnetic stimulation (TMS) to primary motor cortex (M1) at specific intervals to induce plasticity. Induction of cortical plasticity through stimulation of the basal ganglia (BG)-M1 connections has no...