نتایج جستجو برای: deep stratum
تعداد نتایج: 216320 فیلتر نتایج به سال:
INTRODUCTION Transdermal delivery has potential advantages over other routes of administration. It could reduce first-pass metabolism associated with oral delivery and is less painful than injections. However, the outermost layer of the skin, the stratum corneum (SC), limits passive diffusion to small lipophilic molecules. Therefore, methods are needed to safely permeabilize the SC so that ioni...
حلالهای deep eutectic اخیرا بعنوان حلالهای سبز شناخته شده اند.ای حلالها می تواند محیط مناسبی برای واکنشهای آنزیمی باشد بنابراین در این مطالعه اثر این مایعات بر فعالیت، پایداری و ساختار آنزیم لاکاز بررسی شد.
lthough Zn 2 is contained in large amounts in the synaptic terminals of hippocampal mossy fibers (MFs), its physiological role in synaptic transmission is poorly understood. By using the newly developed high-sensitivity Zn 2 indicator ZnAF-2, the spatiotemporal dynamics of Zn 2 was monitored in rat hippocampal slices. When high-frequency stimulation was delivered to the MFs, the concentration o...
This 26-wk observational study in children and adolescents with type 1 diabetes (T1D) in Sweden investigated the safety and efficacy of insulin detemir (IDet) in newly diagnosed (ND) patients and those with established diabetes (ED) switching to IDet. A total of 159 patients initiated IDet as part of basal-bolus therapy, 59 in the ND stratum (mean age 9.7 yr) and 97 in the ED stratum (mean age ...
Hippocampal network activity is predominantly coordinated by γ-amino-butyric acid (GABA)ergic neurons. We have previously hypothesized that the altered excitability of hippocampal neurons in Alzheimer's disease (AD), which manifests as increased in vivo susceptibility to seizures in the TgCRND8 mouse model of AD, may be related to disruption of hippocampal GABAergic neurons. In agreement, our p...
In the present study, we used immunohistochemistry and western blot analysis to examine changes in the levels and cellular localization of iron, heavy chain ferritin (ferritin-H), and transferrin in the gerbil hippocampal CA1 region from 30 minutes to 7 days following transient forebrain ischemia. Relative to sham controls, iron reactivity increased significantly in the stratum pyramidale and s...
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