BACKGROUND Optimal starting point for antiretroviral treatment (ART) has been uncertain. METHODS Parallel group, single blind, randomised controlled study of adult HIV positive patients consulting at the Protestant Hospital, Ngaoundere, Cameroon in 2007-8. Simple randomisation of patients in WHO clinical stage 1-2 to start of ART early or deferred, i.e. when CD4 counts dropped below 350 versu...

A light-harvesting complex composed of a π-stacked multichromophoric array in a DNA three-way junction is described. The modular design allows for a ready exchange of non-covalently attached energy acceptors.

We present a simple method to resolve discrete intensity shifts from time-resolved single-molecule emission data. This new method uses multiples of the standard deviation of the measured intensities that are integrated into short time bins. By applying the technique to trimeric units of the main light-harvesting complex (LHCII) of plants, it is shown that the amount of information that can be e...

Redox-regulated reversible phosphorylation of the light-harvesting complex II (LHCII) controls the excitation energy distribution between photosystem (PS) II and PSI. The PsaL and PsaH subunits of PSI enable the association of pLHCII to PSI. Here, we show that the failure of the psal mutant to dock pLHCII to PSI induces excessive phosphorylation of LHCII, primarily due to a marked downregulatio...

The object of this study was evaluation of a walking tractor drawn peanut harvester at different conditions of soil moisture content and forward speed and comparing it with manual harvesting. The evaluation factors for peanut harvester were two levels of soil moisture content and three levels of forward speed. The results revealed that the effect of soil moisture content was only significant on...

Traditional approaches to task planning assume the planner has access to all of the world information needed to develop a complete, correct plan|a plan which can then be executed in its entirety by a robot. We consider problems where some crucial information is missing at plan time but can be obtained from sensors during execution. We discuss the solution of these problems through deferred plan...

Deferred decision making (DDM) refers to when an individual collects evidence about two or more risky alternatives and decides when to stop and make a final choice. Real world examples include physicians running tests before diagnosing an illness, or commanders collecting intelligence before taking military action. We conducted a DDM study aimed at investigating how people know when to defer a ...

A new class of iterative time parallel methods for initial value ordinary differential equations are developed. Methods based on a parallel variation of spectral deferred corrections (SDC) are compared and contrasted with the parareal method. It is shown that there is a strong similarity between the serial step in the parareal algorithm and the correction step in the SDC method. This observatio...

The time-resolved fluorescence intensity fluctuations from single, immobilized complexes of the main light-harvesting complex (LHCII) of plants were investigated in different pH environments close to room temperature and under different light conditions. The efficiency of light harvesting, which was represented by complexes typically residing for long periods in strongly fluorescing states, was...

Employing the utility of the native chemical ligation, site-specific attachment of an ultrastable perylene dye to a derivative of the major light-harvesting complex (LHCII) was demonstrated. Biochemical analysis of the conjugate indicated that the structure and function of LHCII remain largely unaffected by the N-terminal modification.