The rapidly increasing amount of data on human genetic variation has resulted in a growing demand to identify pathogenic mutations computationally, as their experimental validation is currently beyond reach. Here we show that alpha helices and beta strands differ significantly in their ability to tolerate mutations: helices can accumulate more mutations than strands without change, due to the h...

Strong gravitational lensing and stellar dynamics provide two complementary and orthogonal constraints on the density profiles of galaxies. Based on spherically symmetric, scale-free, mass models, it is shown that the combination of both techniques is powerful in breaking the mass-sheet and mass-anisotropy degeneracies. Second, observational results are presented from the Lenses Structure & Dyn...

The accelerating expansion of the universe suggests that an unknown component with strongly negative pressure, called dark energy, currently dominates the dynamics of the universe. Such a component makes up ∼ 70% of the energy density of the universe yet has not been predicted by the standard model of particle physics. The best method for exploring the nature of this dark energy is to map the r...

We extract, from a quark model potential that reproduces the number and ordering of nonstrange baryonic resonances up to 2.3 GeV, the quantum numbers for the dominant configurations in the ground and first non-radial excited states. From the pattern of quantum numbers we identify, from data, spectral regularities that allow us to predict the expected high spin low-lying spectrum from 2.3 to 3.0...

P roteins are 30% -helices, which, together with -sheets and loops, self-assemble into specific topological arrangements that make biologically active 3dimensional structures. The -helix has another important feature: it is capable of folding autonomously (1). Despite the apparently simpler structure, -helix formation is governed by the same physical principles as protein folding, and recruits ...

The rapidly increasing amount of data on human genetic variation has resulted in a growing demand to identify pathogenic mutations computationally, as their experimental validation is currently beyond reach. Here we show that alpha helices and beta strands differ significantly in their ability to tolerate mutations: helices can accumulate more mutations than strands without change, due to the h...

A technique has been developed to fabricate polymeric helices with sub-micron dimensions. These helices are made using a double-templating process, in which an inorganic thin film deposited using glancing angle deposition acts as the master. The shape, pitch, handedness and number of turns of the polymer helices can be tuned by altering the deposition parameters of the master film. The structur...