Poorly water-soluble drugs often suffer from limited or irreproducible clinical response due to their low solubility and dissolution rate. In this study, organic solvent-free solid dispersions (OSF-SDs) containing telmisartan (TEL) were prepared using polyvinylpyrrolidone K30 (PVP K30) and polyethylene glycol 6000 (PEG 6000) as hydrophilic polymers, sodium hydroxide (NaOH) as an alkalizer, and ...

During the past few years, the studies of bi- and multi-layered tablets increased due to the consumption of several different drugs per day by a patient and requests for appropriate patient compliance. The demographic shift toward older population increases the use of combination therapy as polypharmacy. Hydrochlorothiazide (HCTZ), as a model drug, is most commonly used in the treatment of hype...

      The in vitro dissolution of plasma-sprayed hydroxyapatite (PHA) coatings with different characteristics, produced by various spraying conditions, in a Tris-buffered solution at pH 7.4 was experimentally studied through the measurement of calcium ions release with Inductively Coupled Plasma Atomic Emission Spectroscopy (ICP-AES), and then modeled. Three coating characteristics, th...

the formulation of hydrophobic drugs for oral drug delivery is challenging due to poor solubility, poor dissolution and poor wetting of these drugs. consequently, the aim of this study was to improve the dissolution of a model poorly water soluble drug, ibuprofen. microparticles containing ibuprofen were produced by spray drying and spray chilling technology in the absence/presence of a hydroph...

The effects of crystallization of indomethacin as a poorly water-soluble drug in aqueous surfactant solutions (using the basket method), on the drug dissolution behavior was investigated.A significant enhancement of drug dissolution was observed for for the dissolution rates of crystals treated with hydrophilic surfactants, Tween 80 and sodium lauryl sulfate (SLS). However, asing Arlacel 60 as ...

The effects of crystallization of indomethacin as a poorly water-soluble drug in aqueous surfactant solutions (using the basket method), on the drug dissolution behavior was investigated.A significant enhancement of drug dissolution was observed for for the dissolution rates of crystals treated with hydrophilic surfactants, Tween 80 and sodium lauryl sulfate (SLS). However, asing Arlacel 60 as ...

The potential of liquisolid systems to improve the dissolution properties of a water-insoluble agent (indomethacin) was the purpose of this survey. In this study, different formulations of liquisolid tablets using different co-solvents (non-volatile solvents) were prepared and the effect of several amounts of them on the dissolution behaviour of indomethacin was investigated. It is worth mentio...

the effects of crystallization of indomethacin as a poorly water-soluble drug in aqueous surfactant solutions (using the basket method), on the drug dissolution behavior was investigated.a significant enhancement of drug dissolution was observed for for the dissolution rates of crystals treated with hydrophilic surfactants, tween 80 and sodium lauryl sulfate (sls). however, asing arlacel 60 as ...

Piroxicam is a nonsteroidal anti-inflammatory drug with low aqueous solubility which exhibits polymorphism. The present study was carried out to develop polymorphs of piroxicam with enhanced solubility and dissolution rate by the crystal modification technique using different solvent mixtures prepared with PEG 4000 and PVP K30. Physicochemical characteristics of the modified crystal forms of pi...