The hereditary spastic paraplegias are a group of heterogeneous disorders characterised by lower limb spasticity. Although most cases represent a ‘pure’ form, variants with additional ‘complicating’ features have been documented [1]. We report a patient with hereditary spastic paraplegia (HSP) having a demyelinating form of polyneuropathy which has not been previously associated with this condi...

Central or peripheral demyelinating disorders including neuromyelitis optica, isolated optic neuritis or myelitis, and Guillain-Barre syndrome (GBS) in patients with tuberculosis have been well documented in the literature. , 2 It has been suggested that they are most likely due to an immune reaction to tuberculosis rather than due to direct invasion of tuberculosis or the adverse effect of ant...

Multiple sclerosis (MS) is a demyelinating disease showing variable clinical presentation. Optic neuritis is the most common symptom, followed by motor and sensitive manifestations. It is known that this disease may be related to several psychiatric disorders, especially depression. In this study we will discribe 5 cases of MS patients harboring psychiatric disorder related or unchained by the ...

The purpose of this review is to illustrate the wide spectrum of lesions in the corpus callosum, both congenital and acquired: developmental abnormalities, phakomatoses, neurometabolic disorders, demyelinating diseases, infection and inflammation, vascular lesions, neoplasms, traumatic and iatrogenic injury, and others. Cases include fetuses, children, and adults with rich iconography from the ...

The association between multiple sclerosis (MS) and hereditary and sporadic demyelinating disorders of the peripheral nervous system is extremely rare. We herein report a case of Charcot-Marie-Tooth disease type 1B with p.Val102fs mutation in the MPZ gene that developed relapsing remitting MS.

In central nervous system (CNS) demyelinating disorders, such as multiple sclerosis (MS), neuromyelitis optica (NMO) and related NMO-spectrum disorders (NMO-SD), a pathogenic role for antibodies is primarily projected into enhancing ongoing CNS inflammation by directly binding to target antigens within the CNS. This scenario is supported at least in part, by antibodies in conjunction with compl...

PATIENT Male, 50. FINAL DIAGNOSIS Acute post-vaccination CNS demyelinating disorder. SYMPTOMS Blurred vision • hemiparesis • hemiplegia • hypertonia • itching • paresthesia. MEDICATION -. CLINICAL PROCEDURE MRI. SPECIALTY Neurology. OBJECTIVE Rare disease. BACKGROUND There are several categories of primary inflammatory demyelinating disorders, which comprise clinically similar neu...

Hepatitis C virus (HCV) infection is common in the general population and may coincide with disease in the central and peripheral nervous system. Interferon-alpha (IFN-alpha) is used as treatment for HCV infection. The therapeutic benefit is assumed to result from activation of natural killer cells and CD8+ T cells. Despite its beneficial effects, it has been associated with a number of autoimm...