The present case report describes the interdisciplinary management of a patient with increased overbite and overjet, Angle’s Class Ⅰ malocclusion, bilateral agenesis mandibular central incisors microdontia upper lateral incisors. 18-year-old female had convex profile, maxillary dentoalveolar protrusion mild spacing in anterior region. Therefore, treatment consisted fixed appliance therapy, foll...

WNT10A is a signaling molecule involved in tooth development, and WNT10A defects are associated with tooth agenesis. We characterized Wnt10a null mice generated by the knockout mouse project (KOMP) and six families with WNT10A mutations, including a novel p.Arg104Cys defect, in the absence of EDA,EDAR, or EDARADD variations. Wnt10a null mice exhibited supernumerary mandibular fourth molars, and...

The agenesis of maxillary lateral incisors affects the Quality Life and self-esteem patients. management such patients can be done by either opening space replacing it with prosthesis or closing substituting canine as a incisor. choice treatment decision depends upon proper diagnosis planning case. In this case report, skeletal class II patient dental Angle’s malocclusion spacing in arch due to...

Transposition of teeth is a severe problem, which usually affects the cuspid-first premolar area. It is frequently associated with other dental anomalies such as tooth agenesis, peg-shaped maxillary lateral incisors, retained deciduous teeth, malpositions of the adjacent teeth and other teeth malformations. This paper describes the orthodontic management with fixed appliances of a case of bilat...

INTRODUCTION We analyzed the etiopathogenetic, clinical, radiographic, and histopathologic aspects of keratocystic odontogenic tumors, particularly in association with dental anomalies of number, with the aim of providing useful information for their correct diagnosis, treatment, and prognosis within a multidisciplinary approach. CASE PRESENTATION A 14-year-old Caucasian girl presented for ob...

OBJECTIVE The aim of this prospective controlled study is the comparison between long-term children survived leukaemia and a control group in terms of the decayed, missing or filled permanent teeth (DMFT) and dental anomalies. STUDY DESIGN Fifty-two long term children survived leukaemia, aged from 8 to 15 years (27 females, 25 males; mean age 11.5 years) were evaluated for the possible effect...

There are more than 500 anomalies caused by simple genetic factors and perhaps an equal number of others derived from multifactorial causes or chromosome aberrations where there are orofacial alterations. The frequency of symptom-less carriers of heredity anomalies that affect the teeth can be calculated from genetic data that is often essential to advise on the probability of affected offsprin...

BACKGROUND Aicardi Syndrome is an X-linked autosomal recessive neurodegenerative encephalopathy. The diagnostic triad is composed by infantile spasms, agenesis of corpus callosum and chorioretinal lacunae. Additional common findings are: microencephaly, spasticity and severe mental delay. It affects only females because of early embryonic lethality in males. A significant number of females with...

Multimodal cancer therapy for pediatric head and neck tumors may be associated with significant developmental orofacial morbidity. This report details these effects in a child (C.I.) diagnosed at 2.5 years of age with a rhabdomyosarcoma, primary to the left buccinator. This case is of interest as C.I. has an unaffected identical twin (D.I.) for comparative study. Both were assessed by comparing...