Data from living and extinct faunas of primitive vertebrates imply very different scenarios for the origin and evolution of the dermal and oral skeletal developmental system. A direct reading of the evolutionary relationships of living primitive vertebrates implies that the dermal scales, teeth, and jaws arose synchronously with a cohort of other characters that could be considered unique to ja...

PURPOSE The purpose of this pilot study is to propose a technique, the split-finger approach, to preserve/promote papillae formation. MATERIALS AND METHODS Twenty-one patients with 39 implants consecutively placed in the maxillary anterior region were evaluated at 6 months to 1 year after prosthodontic restoration. The implants evaluated included 16 single-tooth implants, 1 2-unit implant pro...

The semaphorins are a large family of secreted or cell-bound signals needed for the development of the nervous system. We compared mRNA expression of class 3 semaphorins (Sema3A, 3B, 3C and 3F) and their two receptors (Neuropilin-1 and -2) in the embryonic mouse first molar tooth germ (E10-18) by radioactive in situ hybridization. All genes showed distinct developmentally regulated expression p...

Stem cell biology has become an important field in regenerative medicine and tissue engineering therapy since the discovery and characterization of mesenchymal stem cells. Stem cell populations have also been isolated from human dental tissues, including dental pulp stem cells, stem cells from human exfoliated deciduous teeth, stem cells from apical papilla, dental follicle progenitor cells, an...

In the developing tooth, 1-hydroxyethylidene-1,1-bisphosphonate (HEBP) causes hypoplasia and hypomineralization of enamel and dentine. The present study was undertaken to clarify the effects of HEBP on the formation of dental tissues of tooth germs in an organ culture system. Mandibular first molars from 17.5-day-old mouse embryos were cultured with or without 250 microM HEBP in culture medium....

The development of the lower incisor in the mouse was investigated from histological sections using computer-aided 3D reconstructions. At ED 13.0, the incisor was still at the bud stage. At ED 13.5, the initial cap was delimited by a short cervical loop, the development of which proceeded on the labial side, but was largely retarded on the medial side. This difference was maintained up to ED 15...

Primordial odontogenic tumor (POT) is a rare characterized by variably cellular loose fibrous tissue with areas similar to the dental papilla and covered cuboidal columnar epithelium. We herein report case of POT in 14-year-old boy. Computed tomography (CT) exhibited round cavity defined cortical border circumscribing tooth second molar. However, gross finding was solid mass, not cyst. Histolog...

Introduction: Ability to reconstruct the papilla in anterior maxilla is important aspect of perio-plastic surgery. In most articles, connective tissue is used with different designs of incisions. The aim of this study was to use sub-epithelial connective tissue graft (SCTG) with two types of incisions called papilla preservation and semilunar. Materials & Methods: This basic randomized clinica...

Classical tooth development theory suggests that dental papilla cells (DPCs) are the precursor cells of odontoblasts, which are responsible for dentin development. However, our previous studies have indicated that dental follicle cells (DFCs) can differentiate into odontoblasts. To further our understanding of tooth development, and the differences in dentinogenesis between DFCs and DPCs, the o...

Soft tissue volume and quality are considered important factors for functional esthetic long-term outcomes around natural teeth dental implants. However, achieving them is challenging oral surgeons. Healing of an extraction site combined with normal physiological ridge resorption loss interdental papillae scaffold. Therefore, the rehabilitation these ridges implants or pontic fixed prosthesis u...