BACKGROUND Allergen immunotherapy (AIT) is effective treatment for allergic diseases, and subcutaneous use of depigmented polymerized extracts may allow rapid up-dosing and safe therapy. To date, there is little information on their safety and clinical effects for children and adolescents with allergic disease. METHODS We performed a retrospective survey of patient notes of 2927 children and ...

Vitiligo is an acquired depigmentary disorder of the skin that results from the loss of functioning epidermal melanocytes. Most studies on vitiligo have concentrated on the abnormality of melanocytes rather than the abnormality of keratinocytes; however, epidermal melanocytes form a functional and structural unit with neighboring keratinocytes. In fact, direct cell-to cell contact stimulates in...

To the Editor: After reading the article by Laguna et al,1 published in this journal, we wished to contribute a new example, and to propose a series of considerations for improved management of these patients. We present the case of a 29-year-old patient, with no relevant personal history, who consulted for multifocal pigmented macules of varying coloration on the penis; these were symptom free...

Atopic dermatitis (AD) is a chronic immune-mediated disease characterized by intense pruritis, causing inflammation, itching, and redness of the skin. Dupilumab human monoclonal antibody that has been approved for treatment atopic dermatitis. It also linked with various adverse effects, most them confined to injection site. Café-au-lait-macules are benign pigmented lesions skin, usually seen in...

Dear Editor, Reticulate pigmentary disorders (RPD) is a term used to classify a spectrum of several acquired and congenital disorders. Different clinical features can be present, including a reticular pattern and a freckle-like pattern with hyperor hypo-pigmented macules (1). Dowling-Degos disease (DDD), an autosomal dominant genodermatosis, is the main type of RPD (2). Clinically, DDD presents...

BACKGROUND Circumscribed oral melanotic macules in adults are a well-defined entity. Congenital oral melanotic macules, however, are rare and not well characterized. We report 5 cases of congenital lingual melanotic lesions with consistent clinical and histologic features. OBSERVATIONS Congenital lingual melanotic macules presented in all cases at birth, followed by proportional growth. Clini...