The soft-clustered vehicle routing problem (Soft-CluVRP) is a relaxation of the clustered (CluVRP), which in turn variant generalized (GVRP). aim Soft-CluVRP to look for minimum cost group routes starting and ending at given depot set customers partitioned into priori defined, mutually exclusive exhaustive clusters, satisfying capacity constraints vehicles with supplementary property that all f...

The Vehicle Routing Problem with Stochastic Demands (VRPSD) is a variation of the classical Capacitated Vehicle Routing Problem (CVRP) in which the demand of each customer is modeled as a random variable and its realization is only known upon vehicle arrival to the customer site. Under this uncertain scenario, a possible outcome is that the demand of a customer ends up exceeding the remaining c...

This essay discusses the preliminary results of recent archaeological investigations into stone axe production and exchange processes at a Neolithic hilltop settlement in South India. The site in question comprises a stone-lined circular structure situated on a plateau area on the side of a topographically complex hill, known locally as Hiregudda. Across the plateau, extensive surface scatters ...

Recent technology change and market liberalization have substantially reduced the costs of providing international message telephone services (IMTS). However, the full extent of these cost reductions have generally not been reflected in lower prices. This paper reviews the recent literature on international telecommunications markets, and examines regulation and IMTS pricing behaviour. Particul...

Marcus Poggi de Aragão Dep.de Informática Pontif́ıcia Universidade Católica do Rio de Janeiro [email protected] Eduardo Uchoa Dep. Eng. de Produção Universidade Federal Fluminense [email protected] January 15th, 2005 The Capacitated Vehicle Routing Problem (CVRP) is the most basic variant of a vehicle routing problem: homogeneous fleet, single depot, only deliveries, no time-windows, and ...

OBJECTIVES To compare the pharmacodynamics and tolerability of the new goserelin acetate 10.8-mg depot with the 3.6-mg depot in patients with advanced prostate cancer during the first 3 months of therapy. METHODS One hundred sixty patients were randomized in two comparative studies to receive either the 10.8-mg goserelin acetate depot every 12 weeks or the 3.6-mg goserelin acetate depot every...

Long-acting depot antipsychotics were developed specifically to promote treatment adherence (compliance) and they are a valuable option for patients requiring maintenance medication for schizophrenia. Depot use has fallen in recent years, perhaps owing to the introduction of oral atypical antipsychotics. Psychiatrist and patient acceptance of depot medication is variable. The depot formulation ...

long protocol of gonadotropin-releasing hormone-analougue (gnrh-a) can result in the formation of ovarian cyst by the transient initial stimulatory effect which increases the levels of both follicle-stimulating hormone (fsh) and luteinizing hormone (lh). these cysts require surgical drainage or result in poor ovarian response. ovarian cyst formation can be prevented by taking oral contraceptive...

In this paper, we present a methodology for solving a multi-product, multi-depot periodic vehicle routing problem. The problem focuses on allocating products and assigning appropriate delivery days to a set of customers, and designing a set of delivery routes for every day of the planning period. A tabu-search based heuristic is proposed to find the best allocation and routing plan that would g...

In capacitated vehicle routing problem (CVRP), a fleet of vehicles with certain capacity starts at central depot and returns to this starting point after serving some customers by using the optimal set routes minimum cost. However, in real-life, environments may include obstacles such as holes, machines, or trees different sizes. research, CVRP extension is proposed that classical one for vario...