The article addresses the well-known Capacitated Vehicle Routing Problem (CVRP), in the special case where the demand of a customer consists of a certain number of two-dimensional weighted items. The problem calls for the minimization of the cost of transportation needed for the delivery of the goods demanded by the customers, and carried out by a fleet of vehicles based at a central depot. In ...

In this paper, we address the Two-Echelon Vehicle Routing Problem (2E-VRP) in which freight is delivered from depots to intermediary satellites, from where it is delivered to customers. Different from other multi-level problems, the focus in 2E-VRP is on the global routing costs of the overall network. 2E-VRP has been recently introduced and, to our knowledge, there are no studies of the impact...

occurrence of natural disaster inflicts irreparable injuries and symptoms on humans. in such conditions, affected people are waiting for medical services and relief commodities. thus, quick reaction of medical services and relief commodities supply play important roles in improving natural disaster management. in this paper, a multi-objective non-linear credibility-based fuzzy mathematical prog...

In this year-long, prospective observational study, sociodemographic, clinical, and functional characteristics were assessed in outpatients with schizophrenia from Australia, Mexico, Romania, and Taiwan who were switched from their primary oral antipsychotic to another oral or depot antipsychotic at study entry because of physician-perceived nonadherence risks. Patients (N = 406) rated their qu...

of prior cloud work: The PIs have built Depot, a cloud storage system that minimizes trust assumptions. Depot tolerates buggy or malicious behavior by any number of clients or servers, yet it provides safety and liveness guarantees to correct clients. Depot provides these guarantees using a two-layer architecture. First, Depot ensures that the updates observed by correct nodes are consistently ...

The paper describes the design, implementation, and evaluation of Depot, a cloud storage system that minimizes trust assumptions. Depot tolerates buggy or malicious behavior by any number of clients or servers, yet it provides safety and liveness guarantees to correct clients. Depot provides these guarantees using a two-layer architecture. First, Depot ensures that the updates observed by corre...

Using pigmented rabbits, two fluorophotometric methods for measuring aqueous flow were compared. A corneal depot of dye was used to measure aqueous flow in one eye of each rabbit while the vitreous depot method of Johnson and Maurice was used to measure aqueous flow over the same period in the fellow eye. After intravenous administration of acetazolamide or mannitol, during the first hour after...

A new depot formulation of the LHRH analogue Zoladex (goserelin acetate) has been developed which releases the drug over a period of at least 3 months as judged by measurement of drug content in depots at intervals after insertion in male rats and by the suppression of oestrogen secretion and oestrus in female rats. This formulation is based on the lactide/glycolide polymer system used for the ...

BACKGROUND The size and geometry of an insulin depot that is formed during subcutaneous administration by an insulin pump is evaluated. A novel method is used to visualize accurately the depot formation for small volumes of insulin (of the order of 10-100 µl) at a given point in time. Conventional visualization methods such as magnetic resonance imaging are unable to provide such accurate measu...