The mechanism of reductive cleavage of model alkyl halides (methyl 2-bromoisobutyrate, methyl 2-bromopropionate, and 1-bromo-1-chloroethane), used as initiators in living radical polymerization (LRP), has been investigated in acetonitrile using both experimental and computational methods. Both theoretical and experimental investigations have revealed that dissociative electron transfer to these...

Reaction of [Pd(1R,2R-diaminocyclohexane)Cl(2)] with the oxidised form of the tripeptide glutathione ([gamma]-l-glutamyl-l-cysteinyl-glycine) in aqueous solution leads to reductive cleavage of the disulfide bond.

The aims of this project were firstly to develop a protocol for the iterative synthesis of polyethers on a polymeric support, using suitably protected monomers. The synthesis of cyclic ethers by an intramolecular cyclisation/cleavage from the polymeric support, utilising a sulfonyl chloride linker, was also desired. The final aim was to develop a method for reductive amination on a polymeric su...

Studies directed toward the oxidative and reductive desulfurization of readily available 2'-S-aryl-2'-thiouridine derivatives were investigated with the prospect to functionalize the C2'-position of nucleosides. The oxidative desulfurization-difluorination strategy was successful on 2-(arylthio)alkanoate surrogates, while extension of the combination of oxidants and fluoride sources was not an ...

Amino acid analysis (AAA) is one of the best methods to quantify peptides and proteins. Two general approaches to quantitative AAA exist, namely, classical postcolumn derivatization following ion-exchange chromatography and precolumn derivatization followed by reversed-phase HPLC (RP-HPLC). Excellent instrumentation and several specific methodologies are available for both approaches, and both ...

An in-situ derivatization thermal desorption method followed by gas chromatography and time-of-flight mass spectrometry (IDTD-GC-TOFMS) was developed for determination of polar organic compounds together with non-polar compounds in one measurement. Hydroxyl and carboxyl groups of compounds such as anhydrous sugars, alcohols and phenols, fatty acids and resin acids are targets of the derivatizat...