نتایج جستجو برای: derived suppressor cell
تعداد نتایج: 2062797 فیلتر نتایج به سال:
Cancer cells escape immune destruction. From this perspective, myeloid-derived suppressor (MDSCs), which are immunosuppressive in various cancers including breast cancer (BC), significant. However, the precise mechanisms unknown. We isolated HLA-DR - CD33 + MDSCs and CD3 T from BC patients’ peripheral blood healthy donors through MACS immunophenotyped by flow cytometry. Transfection of short-in...
Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune responses in cancer and other pathological conditions. In recent years, ample evidence supports key contributions of MDSC to tumour progression through both immune-mediated mechanisms and those not directly associated with immune suppression. MDSC are the subject of intensive research with >500 papers published ...
TNF, an inflammatory cytokine that is enriched in the tumor microenvironment, promotes tumor growth and subverts innate immune responses to cancer cells. We previously reported that tumors implanted in TNF receptor-deficient (Tnfr-/-) mice are spontaneously rejected; however, the molecular mechanisms underlying this rejection are unclear. Here we report that TNF signaling drives the peripheral ...
Myeloid-derived suppressor cell cytokine secretion as prognostic factor in myelodysplastic syndromes
Myeloid derived suppressor cells (MDSCs) are defined in mice on the basis of CD11b and Gr-1 marker expression and the functional ability to inhibit T lymphocyte activation. Nevertheless the term 'heterogeneous' remains the first, informal feature commonly attributed to this population. It is clear that CD11b(+)Gr-1(+) cells are part of a myeloid macropopulation, which comprises at least two sub...
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