Tyrosine kinases (TKs) are enzymes that catalyze the phosphorylation of tyrosine residues on protein substrates. They are key components of signaling pathways that drive an array of cellular responses including proliferation, differentiation, migration, and survival. Specific TKs have recently been identified as critical to the pathogenesis of several autoimmune and inflammatory diseases. Small...

Ergonomic practice increases the productivity, quality, and longevity of the dermatologic surgeon. When used properly, magnification devices can be ergonomic and beneficial additions to the dermatologic surgeon's practice. Herein, we review the available magnification options for the dermatologic surgeon and evaluate the options based on cost, design, and functional advantages and disadvantages...

Spondyloarthropathies encompass a group of inflammatory diseases with arthritis and other features such as enthesitis and dermatologic and gastrointestinal involvement. Up to 37% of spondyloarthropathy patients may develop uveitis which is typically bilateral asynchronous acute anterior uveitis. Spondyloarthropathies with and without uveitis are more prevalent among males; the reasons for gende...

Pyoderma gangrenosum (PG) is an ulcerative cutaneous condition of unknown etiology (1). It was first described in 1930 (2) and it is associated with systemic diseases as inflammatory bowel disease (IBD). We present the case of a girl with a perineal PG who after failure of infliximab was successfully treated with adalimumab. The most common extraintestinal disorders related with inflammatory bo...

Acute generalized exanthematous pustulosis (AGEP) is a cutaneous reaction principally induced by drugs. Spontaneous resolution is observed in most patients. However, severe cases required systemic corticosteroid administration. Hydroxychloroquine, which is used to treat some dermatologic and rheumatologic diseases because of its anti-inflammatory and immunosuppressive effects, is an uncommon ca...

BACKGROUND The practice of dermatology remains mainly outpatient, although dermatologic consultations often have a large impact on inpatient care. OBJECTIVE To analyze the reasons for dermatologic consultation and the impact of dermatologic evaluation at a major teaching hospital. METHODS Retrospective chart review of 243 consecutive dermatologic consultations from primary ward teams betwee...

Biologic therapy has dramatically changed the way medicine, and specifically dermatology, is practiced today. The use of biologic agents in dermatology is evolving, with psoriasis being the most common indication for which biologics are used currently. However, several other dermatologic diseases seem to be responsive to biologic therapy, and continuing research and development efforts are eluc...

In dermatologic practice conservative treatment of venous leg ulcers is limited to medicamentous and physical therapy. In severe, chronic, infected venous leg ulcers there is a need for additional therapy, most commonly physical therapy. With intent to find a new therapeutic method, great attention has been given to herbal remedies, which have been applied in conventional dermatologic practice ...