PURPOSE To modify existing experimental models to simulate the typical clinical presentation of human rhegmatogenous retinal detachment (RRD), namely an RD caused by a retinal break, in a phakic eye, with a posterior vitreous detachment (PVD); to model RRD in a species that is anatomically similar to humans; and to characterize the glial cell response to RRD. METHODS Mixed-breed pigs underwen...

PURPOSE To determine the natural history of asymptomatic, clinical rhegmatogenous retinal detachment. DESIGN Single observer, prospective, consecutive, observational case series. METHODS Consecutive patients were included who were referred to the author's clinical practice with rhegmatogenous retinal detachment extending greater than two disk-diameters posterior to the equator. Patients who...

We investigated the mediating versus moderating role of psychological detachment in the relationship between job stressors and psychological strain. Our sample consisted of 173 university students invested in challenging programs of advanced professional studies, who could find it difficult to detach from work. Hierarchical regression analyses of cross-sectional survey data affirmed the role of...

monomeric myosin first spotted in electron micrographs almost 30 years ago has finally been united with a proposed function. Tyska and Mooseker (page 395) report that myosin-1A associates with and anchors a raft component in apical membranes. Myosin-1A was previously thought to shuttle Golgi-derived cargos to the plasma membrane (after most of the distance had been covered using microtubule-bas...

Most retinal detachments are preceded by a posterior vitreous detachment (PVD), which causes traction on the retina and, potentially, a retinal tear. The liquefied vitreous can then seep under the retina, causing it to detach. Retinal detachments may initially be localised, but without treatment they may progress and lead to irreversible vision loss. Early recognition and prompt referral are th...

The dynamic nature of cell adhesion and detachment is critically important to a variety of physiological and pathophysiological phenomena. Much, however, still remains uncertain and controversial about the mechanochemical players and processes involved in cellular adhesion and detachment. This leads to the need for quantitative characterization of the adhesion and detachment of anchorage-depend...

CONTEXT Fluoroquinolones are commonly prescribed classes of antibiotics. Despite numerous case reports of ocular toxicity, a pharmacoepidemiological study of their ocular safety, particularly retinal detachment, has not been performed. OBJECTIVE To examine the association between use of oral fluoroquinolones and the risk of developing a retinal detachment. DESIGN, SETTING, AND PATIENTS Nest...

The influence of tobacco-smoke-material (TSM) on the detachment of microparticles from surfaces by turbulent air flow was investigated experimentally. Both clean and dusty glass surfaces were subjected to TSM either before or after the deposition of 64 microm to 76 microm-diameter stainless steel microparticles onto the surfaces. The TSM was generated by mechanically puffing research-grade ciga...

In order to better understand the detachment mechanism of secondary dendrite arm during peritectic solidification, the detachment of secondary dendrite arm from the primary dendrite arms in directionally solidified Sn-36at.%Ni peritectic alloys is investigated at different deceleration rates. Extensive detachment of secondary dendrite arms from primary stem is observed below peritectic reaction...