The pathway followed by macromolecules across the wall of visceral capillaries has been studied by using a set of tracers of graded sizes, ranging in diameter from 100 A (ferritin) to 300 A (glycogen) . Polysaccharide particles, i .e. dextran 75 (mol wt -75,000 ; diam -125 A), dextran 250 (mol wt 250,000 ; diam -225 A), shellfish glycogen (diam -200 A) and rabbit liver glycogen (diam -300 A), a...

Graded dextrans have been used as tracers to identify the primary permeability barrier(s) to macromolecules among the structural elements (endothelium, mesangium, basement membrane, epithelium) of the glomerular capillary wall. Three narrow-range fractions of specified molecular weights and Einstein-Stokes radii (ESR) were prepared by gel filtration: (a) 32,000 mol wt, ESR = 38 A; (b) 62,000 mo...

High molecular weight dextrans improve the rheological properties of fermented products and have immunomodulatory antiviral activity. We report on 5.84 × 107–2.61 108 Da produced by Leuconostoc lactis AV1n, Weissella cibaria AV2ou confusa V30 FS54 strains. Dextransucrases catalyze dextran synthesis sucrose hydrolysis concomitant with fructose generation. The four bacteria dextransucrases about ...

In this study, the rheological properties of three distinct dextrans with different levels (1 → 6)-linked α-D-glucose/(1 3)-linked α-D-glucose units from lactic acid bacteria (LAB) strains were determined. Dextran PDER21 was further selected following measurements and its interactions maize, wheat waxy maize starches determined by characterizing viscoelastic pasting dextran–starch mixtures. Fou...

Adenosine-mediated recruitment of microvascular volume in heart and muscle has been suggested to include, in addition to vasodilation of resistance vessels, an increased accessibility of the endothelial glycocalyx for flowing plasma as a result of an impairment of its barrier properties. The aim of the current study was to investigate the effect of systemic intravenous administration of adenosi...

Cytokine mediated changes in paracellular permeability contribute to a multitude of pathological conditions including chronic rhinosinusitis (CRS). The purpose of this study was to investigate the effect of interferons and of Th1, Th2, and Th17 cytokines on respiratory epithelium barrier function. Cytokines and interferons were applied to the basolateral side of air-liquid interface (ALI) cultu...

The lens capsule compartmentalizes the cells of the avascular lens from other ocular tissues. Small molecules required for lens cell metabolism, such as glucose, salts, and waste products, freely pass through the capsule. However, the lens capsule is selectively permeable to proteins such as growth hormones and substrate carriers which are required for proper lens growth and development. We use...