BACKGROUND Diabetes is associated with a cardiomyopathy that is independent of coronary artery disease or hypertension. In the present study we used in vivo magnetic resonance imaging (MRI) and echocardiographic techniques to examine and characterize early changes in myocardial function in a mouse model of type 1 diabetes. METHODS Diabetes was induced in 8-week old C57BL/6 mice with two intra...

BACKGROUND Cardiac dysfunction in diabetic cardiomyopathy may be associated with abnormal Ca2+ homeostasis. This study investigated the effects of alterations in Ca2+ homeostasis and sarcoplasmic reticulum Ca2+-associated proteins on cardiac function in the development of diabetic cardiomyopathy. METHODS Sprague-Dawley rats were divided into 4 groups (n = 12, each): a control group, and strep...

Cardiovascular disease is one of the major causes of mortality in diabetic patients. Mounting studies have shown that garlic exhibits, possibly through its antioxidant potential, diverse biological activities. In this study, we investigated the alleviating effects of garlic oil (GO) and its two major components, diallyl disulfide (DADS) and diallyl trisulfide (DATS), on diabetic cardiomyopathy ...

Diabetes mellitus increases the risk of heart failure independently of underlying coronary artery disease, and many believe that diabetes leads to cardiomyopathy. The underlying pathogenesis is partially understood. Several factors may contribute to the development of cardiac dysfunction in the absence of coronary artery disease in diabetes mellitus. This review discusses the latest findings in...

BACKGROUND Diabetic women are five times more likely to develop congestive heart failure compared with two fold for men. The underlying mechanism for this gender difference is not known. Here we investigate the molecular mechanisms responsible for this female disadvantage and attempt safeguarding cardiomyocytes viability and function through restoration of pro-survival Pim-1. METHODS AND RESU...

Diabetic heart, which includes any condition causing pathological changes in blood vessels, cardiac muscle or valves and cardiac rhythm in diabetic patients, such as diabetic cardiomyopathy and ischemic heart disease, is an important cause of mortality in diabetic patients. However, strategies for the treatment of diabetic heart have not been well documented. Recent, large, clinical trials, the...

Background This study was conducted to identify cardiac dysfunction and the relationship of hemoglobin A1c (HbA1c) levels and serum lipids to echocardiographic indices in children and adolescents with T1DM. Materials and Methods: This  case-control study was conducted on  100 cases  including 50 children and adoles...

To test the hypothesis that the prevalence of a cardiomyopathic syndrome in association with coronary artery disease is higher among diabetic patients, clinical, ventriculographic, and arteriographic features of coronary artery disease were evaluated in 84 patients with coronary artery disease. Forty-two diabetics were compared with 42 non-diabetics who were randomly selected and matched for ag...