In diabetic patients, impairment of wound healing is a serious problem which represents a significant health burden. The effect of a highly selective beta-3 adrenoceptor agonist, SR58611A, on wound healing was assessed in animal models of type II diabetes. In db/db diabetic mice, a daily oral treatment with SR58611A (1, 3 and 10 mg/kg/day for two weeks) significantly reduced hyperglycaemia from...

Diabetes is a complex metabolic disorder triggered by the deficient secretion of insulin by the pancreatic β-cell or the resistance of peripheral tissues to the action of the hormone. Chronic hyperglycemia is the major consequence of this failure, and also the main cause of diabetic problems. Indeed, several clinical trials have agreed in that tight glycemic control is the best way to stop prog...

Since the discovery of the anti-diabetic effects of zinc (Zn) complex, we synthesized several Zn complexes and evaluated their effects using the KKAy type 2 diabetes mouse model. Recently, we demonstrated that organo-chalcogen (sulfur and selenium) Zn complexes elicit strong anti-diabetic effects. In this study, we treated leptin-deficient ob/ob mice with organo-chalcogen Zn complexes, and eval...

background: the ultimate goal of diabetes control is hba 1c improvement. the purpose of this study was to assess the effect of empowerment model on hba 1c among adolescents with type 1 diabetes. methods: the present semi-experimental study was carried out on some 47 diabetic adolescents in order to investigate the effect of an educational program based on the empowerment model on hba 1c among a...

Background: Diabetes mellitus increases the risk of central nervous system (CNS) disorders such as stroke, seizures, dementia, and cognitive impairment. Berberine, a natural isoquinolne alkaloid, is reported to exhibit beneficial effect in various neurodegenerative and neuropsychiatric disorders. Moreover astrocytes are proving critical for normal CNS function, and alterations in their activity...

Background: Diabetes mellitus increases the risk of central nervous system (CNS) disorders such as stroke, seizures, dementia, and cognitive impairment. Berberine, a natural isoquinolne alkaloid, is reported to exhibit beneficial effect in various neurodegenerative and neuropsychiatric disorders. Moreover astrocytes are proving critical for normal CNS function, and alterations in their activity...

introduction: one of the main mechanisms by which diabetic complications occur is an alteration of the structure and function of proteins due to hyperglycemia. aspirin (asa) affects cellular pathways through different mechanisms, including glycation inhibition and antioxidant activity. the aim of the present study, as a follow up to our previous one, is to investigate the effect of long-term, h...

Objective-This study was conducted to evaluate the effect of co-administration of Aloe vera gel and cinnamon zeynalicum bark hydroethanolic extract on process of wound healing in diabetic mice model.Design- Experimental Study.Animals- Seventy-two male BALB/c mice.Procedures- A single full-thickness excisional wound was created on ba...

The current study evaluated the glucose-lowering effect of ganoderma lucidum polysaccharides (Gl-PS) in streptozotocin (STZ)-induced diabetic mice. The diabetic mice were randomly divided into four groups (8 mice per group): diabetic control group, low-dose Gl-PS treated group (50 mg/kg, Gl-PS), high-dose Gl-PS treated group (150 mg/kg, Gl-PS) and positive drug control treated group (glibenclam...