Fixed drug eruption is a cutaneous reaction which occurs by repetitive exposure to the offending drugs like antimicrobials, anticonvulsants and NSAIDS. Here we are presenting a case of 65 year old male of fixed drug eruptions due to administration of injections diclofenac sodium. Diclofenac is a commonly used anti inflammatory drug for relieving pain.

1. Two female and two male patients with essential hypertension were given dihydralazine plus saline or dihydralazine plus diclofenac intravenously on two separate occasions. The dihydralazine dose (range: 16.2--32.4 mg/2 h) was chosen individually to reduce systolic blood pressure by 20 mmHg from the control value before the investigation; the intravenous diclofenac dose was 75 mg/20 ml of sal...

Two modified methods for assaying sodium diclofenac were developed by GC and HPLC. Diclofenac was converted into methyl ester derivative by methyl iodide in acetone. The ester was extract and subjected to GLC with flame ionization detector. %5 SE-30/chrom W-HP (80-100 mesh) was used as a column in GC. For reversed phase HPLC, the mobile phase was methanol and water (55-45). The separation was p...

This study was aimed to develop a stable enteric coated diclofenac sodium tablets using Sureteic without a subcoating layer. Diclofenac uncoated tablets were developed and manufactured through the non direct compression process. Sureteric white aqueous coating dispersion was used as enteric coating material. Sureteric is a special mixture of Polyvinyl Acetate Phthalate (Phthalavin (R), PVAP), p...

A novel iontophoretic system utilizing ion-exchange membranes is effective for selective transdermal delivery of ionized drugs. In the present study, we examined in vivo availability and safety of ion-exchange iontophoresis in the transdermal delivery of anionic diclofenac, a well known anti-inflammatory medication, to rat dorsal skin. While iontophoresis increased the plasma concentration of d...

The purpose of this study was to find a safe and effective analgesic alternative to non-steroidal anti-inflammatory drugs (NSAIDs) for patients undergoing dento-alveolar surgery who could not tolerate NSAIDs. We have compared on a double blind, randomized basis the efficacy of Tramadol hydrochloride with Diclofenac Sodium. Sixty patients undergoing third molar surgery were divided into two grou...

Non-steroidal anti-inflammatory drugs are commonly prescribed in dental practice after minor oral surgical procedures such as tooth extraction. Diclofenac sodium is one of the non-steroidal antiinflammatory drugs widely used for pain relief in dentistry. Although adverse reactions to these drugs are rare, at times they can cause a life-threatening phenomenon. Stevens-Johnson syndrome is one suc...

BACKGROUND/AIM Acute pancreatitis is the most common adverse event of endoscopic retrograde cholangiopancreatography (ERCP). We aimed to evaluate the efficacy of intramuscular diclofenac sodium for prophylaxis of post-ERCP pancreatitis (PEP) in comparison to the rectal form. MATERIALS AND METHODS One hundred and fifty consecutive patients who underwent ERCP were enrolled in this single-center...

BACKGROUND postoperative sore throat is the commonest complication after endotracheal intubation. The efficacy of intravenous non-steroidal anti-inflammatory drugs in alleviating postoperative sore throat has not been investigated. OBJECTIVE To evaluate the effect of intravenous diclofenac sodium on the occurrence and severity of postoperative sore throat. METHODS 42 in-patients scheduled f...