PURPOSE This study quantifies in vivo ischemic stroke brain injuries in rats using ultrahigh-field single-scan MRI methods to assess variations in apparent diffusion coefficients (ADCs). METHODS Magnitude and diffusion-weighted spatiotemporally encoded imaging sequences were implemented on a 21.1 T imaging system, and compared with spin-echo and echo-planar imaging diffusion-weighted imaging ...

RATIONALE AND OBJECTIVES To compare the apparent diffusion coefficient (ADC) and the perfusion fraction measured by intra-voxel incoherent motion (IVIM) Magnetic Resonance Imaging (MRI) with liver fibrosis degrees in a rodent model. MATERIALS AND METHODS All experiments received approval from our institutional animal care and use committee. Liver fibrosis was induced in 13 rats by oral gavage...

BACKGROUND AND OBJECTIVE To prospectively investigate the relationship between the apparent diffusion coefficient (ADC) and cellularity in lung cancer. METHODS Sixty patients histopathologically confirmed with lung cancer (41 men, 19 women) underwent diffusion-weighted magnetic resonance imaging of the chest (with b values of 50 and 1000 s/mm2). The median mean ADC (ADC mean) value and median...

Introduction: While recent studies have supported the utility of diffusion-weighted imaging (DWI) in the detection of prostate cancer (PCa), these studies have employed varying methodology for the acquisition, processing, and interpretation of DWI. For instance, these studies have differed in whether the interpreting radiologists reviewed both the native diffusion-weighted images (nDWI) and app...

BACKGROUND The purpose of the study was to evaluate the value of diffusion-weighted imaging in the differential diagnosis of haemangiomas from metastases of the liver. PATIENTS AND METHODS.: We analyzed 69 lesions in 38 patients (33 haemangiomas; 36 metastases) in the retrospective study. Diffusion-weighted imaging was performed using a breath-hold single-shot echo-planar spin echo sequence wi...

Variations in apparent diffusion coefficient of water (ADC) and blood-brain barrier (BBB) permeability after ischemia have been suggested, though the correlation between ADC alterations and BBB opening remains to be studied. We hypothesized that there are correlations between the alteration of ADC and BBB permeability. Rats were subjected to 2 h of transient middle cerebral artery occlusion and...

OBJECTIVE To investigate the utility of apparent diffusion coefficient (ADC) measurement in the diagnosis of chronic viral hepatitis (CVH) and correlation between ADC values and histopathologic severity of CVH. MATERIALS AND METHODS The ADC values of liver parenchyma on diffusion-weighted magnetic resonance imaging (DWMRI) were measured in 50 patients with a history of CVH and 51 healthy subj...

BACKGROUND AND PURPOSE MR diffusion-weighted (DW) imaging with apparent diffusion coefficient (ADC) has had widespread use clinically in a variety of intracranial diseases; however, only a few studies report ADC changes in patients with hippocampal sclerosis. We sought to determine the ability of ADC to lateralize the epileptogenic lesion in patients with hippocampal sclerosis. METHODS Ninete...

Objectives: This study aims to evaluate the role of diffusion-weighted imaging in detection of active sacroiliitis and compare the apparent diffusion coefficient (ADC) and normalized relative ADC (r-ADC) values by using vertebra and iliac wings as reference organs. Patients and methods: The study included 56 patients (26 males, 30 females; mean age 37.7±10.1 years; range 18 to 66 years) with ch...

Diffusion Magnetic Resonance Imaging (dMRI) encodes the displacement of water due to diffusion and is a powerful tool to obtain information on the tissue micro-structure. An important quantity measured in dMRI at the voxel level is the apparent diffusion coefficient (ADC) and it is well-established from imaging experiments that, in the brain, in-vivo, the ADC depends significantly on the diffus...